Gene Review:
GAL4 - Gal4p
Saccharomyces cerevisiae S288c
Synonyms:
Regulatory protein GAL4, YPL248C
- Specific DNA binding of GAL4, a positive regulatory protein of yeast. Giniger, E., Varnum, S.M., Ptashne, M. Cell (1985)
- Genetic isolation of ADA2: a potential transcriptional adaptor required for function of certain acidic activation domains. Berger, S.L., Piña, B., Silverman, N., Marcus, G.A., Agapite, J., Regier, J.L., Triezenberg, S.J., Guarente, L. Cell (1992)
- Mechanism of action of a yeast activator: direct effect of GAL4 derivatives on mammalian TFIID-promoter interactions. Horikoshi, M., Carey, M.F., Kakidani, H., Roeder, R.G. Cell (1988)
- GAL4 activates gene expression in mammalian cells. Kakidani, H., Ptashne, M. Cell (1988)
- Alterations in a yeast protein resembling HIV Tat-binding protein relieve requirement for an acidic activation domain in GAL4. Swaffield, J.C., Bromberg, J.F., Johnston, S.A. Nature (1992)
- The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing. Muratani, M., Kung, C., Shokat, K.M., Tansey, W.P. Cell (2005)
- An unexpected role for ubiquitylation of a transcriptional activator. Arndt, K., Winston, F. Cell (2005)
- Targeted stimulation of meiotic recombination. Peciña, A., Smith, K.N., Mézard, C., Murakami, H., Ohta, K., Nicolas, A. Cell (2002)
- Sex reversal by loss of the C-terminal transactivation domain of human SOX9. Südbeck, P., Schmitz, M.L., Baeuerle, P.A., Scherer, G. Nat. Genet. (1996)
- Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products. Muchardt, C., Seeler, J.S., Nirula, A., Shurland, D.L., Gaynor, R.B. J. Virol. (1992)
- Autonomous parvovirus transduction of a gene under control of tissue-specific or inducible promoters. Maxwell, I.H., Spitzer, A.L., Long, C.J., Maxwell, F. Gene Ther. (1996)
- A chimeric fusion protein containing transforming growth factor-alpha mediates gene transfer via binding to the EGF receptor. Fominaya, J., Uherek, C., Wels, W. Gene Ther. (1998)
- Overproduction and single-step purification of GAL4 fusion proteins from Escherichia coli. Reece, R.J., Rickles, R.J., Ptashne, M. Gene (1993)
- Alteration of specific amino acid residues in the acidic domain I of VSV phosphoprotein (P) converts a GAL4-P(I) hybrid into a transcriptional activator. Takacs, A.M., Perrine, K.G., Barik, S., Banerjee, A.K. New Biol. (1991)
- Identification of the gal4 suppressor Sug1 as a subunit of the yeast 26S proteasome. Rubin, D.M., Coux, O., Wefes, I., Hengartner, C., Young, R.A., Goldberg, A.L., Finley, D. Nature (1996)
- Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex. Côté, J., Quinn, J., Workman, J.L., Peterson, C.L. Science (1994)
- Control of yeast GAL genes by MIG1 repressor: a transcriptional cascade in the glucose response. Nehlin, J.O., Carlberg, M., Ronne, H. EMBO J. (1991)
- Cooperative DNA binding of the yeast transcriptional activator GAL4. Giniger, E., Ptashne, M. Proc. Natl. Acad. Sci. U.S.A. (1988)
- Regulated expression of the GAL4 activator gene in yeast provides a sensitive genetic switch for glucose repression. Griggs, D.W., Johnston, M. Proc. Natl. Acad. Sci. U.S.A. (1991)
- The yeast UASG is a transcriptional enhancer in human HeLa cells in the presence of the GAL4 trans-activator. Webster, N., Jin, J.R., Green, S., Hollis, M., Chambon, P. Cell (1988)
- Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization. Silver, P.A., Keegan, L.P., Ptashine, M. Proc. Natl. Acad. Sci. U.S.A. (1984)
- Glutamine-rich domains activate transcription in yeast Saccharomyces cerevisiae. Xiao, H., Jeang, K.T. J. Biol. Chem. (1998)
- Phosphorylation of Ga14p at a single C-terminal residue is necessary for galactose-inducible transcription. Sadowski, I., Costa, C., Dhanawansa, R. Mol. Cell. Biol. (1996)
- Perinuclear localization of chromatin facilitates transcriptional silencing. Andrulis, E.D., Neiman, A.M., Zappulla, D.C., Sternglanz, R. Nature (1998)
- Functional domains of the yeast regulatory protein GAL4. Johnston, S.A., Zavortink, M.J., Debouck, C., Hopper, J.E. Proc. Natl. Acad. Sci. U.S.A. (1986)
- A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site. Guarente, L., Yocum, R.R., Gifford, P. Proc. Natl. Acad. Sci. U.S.A. (1982)
- Set2-catalyzed methylation of histone H3 represses basal expression of GAL4 in Saccharomyces cerevisiae. Landry, J., Sutton, A., Hesman, T., Min, J., Xu, R.M., Johnston, M., Sternglanz, R. Mol. Cell. Biol. (2003)
- Action of a RAP1 carboxy-terminal silencing domain reveals an underlying competition between HMR and telomeres in yeast. Buck, S.W., Shore, D. Genes Dev. (1995)
- Characterization of NGG1, a novel yeast gene required for glucose repression of GAL4p-regulated transcription. Brandl, C.J., Furlanetto, A.M., Martens, J.A., Hamilton, K.S. EMBO J. (1993)
- In vivo DNA-binding properties of a yeast transcription activator protein. Selleck, S.B., Majors, J.E. Mol. Cell. Biol. (1987)
- GCN5 dependence of chromatin remodeling and transcriptional activation by the GAL4 and VP16 activation domains in budding yeast. Stafford, G.A., Morse, R.H. Mol. Cell. Biol. (2001)
- GAL1-GAL10 divergent promoter region of Saccharomyces cerevisiae contains negative control elements in addition to functionally separate and possibly overlapping upstream activating sequences. West, R.W., Chen, S.M., Putz, H., Butler, G., Banerjee, M. Genes Dev. (1987)
- Analysis of the GAL3 signal transduction pathway activating GAL4 protein-dependent transcription in Saccharomyces cerevisiae. Bhat, P.J., Oh, D., Hopper, J.E. Genetics (1990)
- The general regulatory factor Reb1p controls basal, but not Gal4p-mediated, transcription of the GCY1 gene in yeast. Angermayr, M., Bandlow, W. Mol. Gen. Genet. (1997)
- Evidence for Gal3p's cytoplasmic location and Gal80p's dual cytoplasmic-nuclear location implicates new mechanisms for controlling Gal4p activity in Saccharomyces cerevisiae. Peng, G., Hopper, J.E. Mol. Cell. Biol. (2000)
- GAL11P: a yeast mutation that potentiates the effect of weak GAL4-derived activators. Himmelfarb, H.J., Pearlberg, J., Last, D.H., Ptashne, M. Cell (1990)
- Mutations that alter transcriptional activation but not DNA binding in the zinc finger of yeast activator HAPI. Kim, K.S., Guarente, L. Nature (1989)
- Identification and characterization of HAP4: a third component of the CCAAT-bound HAP2/HAP3 heteromer. Forsburg, S.L., Guarente, L. Genes Dev. (1989)
- CDC39, an essential nuclear protein that negatively regulates transcription and differentially affects the constitutive and inducible HIS3 promoters. Collart, M.A., Struhl, K. EMBO J. (1993)
- Purification and characterization of the yeast transcriptional activator GAL4. Parthun, M.R., Jaehning, J.A. J. Biol. Chem. (1990)
- The EGD1 product, a yeast homolog of human BTF3, may be involved in GAL4 DNA binding. Parthun, M.R., Mangus, D.A., Jaehning, J.A. Mol. Cell. Biol. (1992)
- Regulated phosphorylation and dephosphorylation of GAL4, a transcriptional activator. Mylin, L.M., Bhat, J.P., Hopper, J.E. Genes Dev. (1989)
- An activator target in the RNA polymerase II holoenzyme. Koh, S.S., Ansari, A.Z., Ptashne, M., Young, R.A. Mol. Cell (1998)