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Gene Review

ECM1  -  Ecm1p

Saccharomyces cerevisiae S288c

Synonyms: Extracellular mutant protein 1, Protein SIM1, SIM1, Shuttling pre-60S factor ECM1, YAL059W
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Disease relevance of ECM1

  • Two strains of Candida albicans and one strain of Candida tropicalis bound avidly to exposed ECM, but Pseudomonas aeruginosa did not [1].
  • The adherence of Candida albicans to extracellular matrix proteins may be a critical step in the pathogenesis of candidiasis [2].
  • It was also detected in areas of fibrosis and necrosis, as well as disperse in amorphous extracellular matrix, mostly in resistant mice [3].

High impact information on ECM1


Biological context of ECM1


Anatomical context of ECM1


Associations of ECM1 with chemical compounds

  • Consistent with these results, we found that the subcellular localization of Cas and 14-3-3 is also regulated by integrin ligand binding and that the two proteins display a significant co-localization during cell attachment to the extracellular matrix [17].
  • The natural product antibiotic sinefungin is an AdoMet analog that inhibits Ecm1 with modest potency [7].
  • SDS extracts that interacted with all the extracellular matrix protein were tested; their molecular masses were 19 and 32 kDa [18].
  • Bovine vascular endothelial cells treated with EDTA, urea, or thrombin underwent a marked, reversible contraction resulting in exposure of the subendothelial extracellular matrix (ECM) [1].
  • Furthermore, in these experimental conditions, the effect of sub-inhibitory concentrations of antifungals on adherence was dependent on the tested antifungal and the adherence surface: amphotericin B inhibited adherence to polystyrene and fibrinogen, but improved adherence to extracellular matrix [19].

Other interactions of ECM1

  • A null mutation in KTR2 leads to partial resistance to killer toxin and hints that KTR2, which encodes a putative mannosyltransferase, is involved in extracellular matrix assembly [20].
  • Because Bud10p contains a large extracellular domain, it is possible that Bud10p functions in a manner analogous to an extracellular matrix receptor [21].

Analytical, diagnostic and therapeutic context of ECM1


  1. Endothelial cell contraction increases Candida adherence to exposed extracellular matrix. Klotz, S.A., Maca, R.D. Infect. Immun. (1988) [Pubmed]
  2. Gelatin fragments block adherence of Candida albicans to extracellular matrix proteins. Klotz, S.A., Smith, R.L. Microbiology (Reading, Engl.) (1995) [Pubmed]
  3. Immunohistochemical demonstration of TGF-beta and decorin in paracoccidioidal granulomas. Nishikaku, A.S., Burger, E. Braz. J. Med. Biol. Res. (2003) [Pubmed]
  4. An MMP liberates the Ninjurin A ectodomain to signal a loss of cell adhesion. Zhang, S., Dailey, G.M., Kwan, E., Glasheen, B.M., Sroga, G.E., Page-McCaw, A. Genes Dev. (2006) [Pubmed]
  5. Alpha-glucosidase I is required for cellulose biosynthesis and morphogenesis in Arabidopsis. Gillmor, C.S., Poindexter, P., Lorieau, J., Palcic, M.M., Somerville, C. J. Cell Biol. (2002) [Pubmed]
  6. NPFXD-mediated Endocytosis Is Required for Polarity and Function of a Yeast Cell Wall Stress Sensor. Piao, H.L., Machado, I.M., Payne, G.S. Mol. Biol. Cell (2007) [Pubmed]
  7. Mutational Analysis of Encephalitozoon cuniculi mRNA Cap (Guanine-N7) Methyltransferase, Structure of the Enzyme Bound to Sinefungin, and Evidence That Cap Methyltransferase Is the Target of Sinefungin's Antifungal Activity. Zheng, S., Hausmann, S., Liu, Q., Ghosh, A., Schwer, B., Lima, C.D., Shuman, S. J. Biol. Chem. (2006) [Pubmed]
  8. Domestication of wild Saccharomyces cerevisiae is accompanied by changes in gene expression and colony morphology. Kuthan, M., Devaux, F., Janderová, B., Slaninová, I., Jacq, C., Palková, Z. Mol. Microbiol. (2003) [Pubmed]
  9. Defects in assembly of the extracellular matrix are responsible for altered morphogenesis of a Candida albicans phr1 mutant. Popolo, L., Vai, M. J. Bacteriol. (1998) [Pubmed]
  10. Functional interaction between Smad, CREB binding protein, and p68 RNA helicase. Warner, D.R., Bhattacherjee, V., Yin, X., Singh, S., Mukhopadhyay, P., Pisano, M.M., Greene, R.M. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  11. Yeast cell inactivation related to local heating induced by low-intensity electric fields with long-duration pulses. Guyot, S., Ferret, E., Boehm, J.B., Gervais, P. Int. J. Food Microbiol. (2007) [Pubmed]
  12. The global transcriptional response to transient cell wall damage in Saccharomyces cerevisiae and its regulation by the cell integrity signaling pathway. García, R., Bermejo, C., Grau, C., Pérez, R., Rodríguez-Peña, J.M., Francois, J., Nombela, C., Arroyo, J. J. Biol. Chem. (2004) [Pubmed]
  13. Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers. Yi, J., Kloeker, S., Jensen, C.C., Bockholt, S., Honda, H., Hirai, H., Beckerle, M.C. J. Biol. Chem. (2002) [Pubmed]
  14. Interaction of the Arabidopsis receptor protein kinase Wak1 with a glycine-rich protein, AtGRP-3. Park, A.R., Cho, S.K., Yun, U.J., Jin, M.Y., Lee, S.H., Sachetto-Martins, G., Park, O.K. J. Biol. Chem. (2001) [Pubmed]
  15. Apyrase functions in plant phosphate nutrition and mobilizes phosphate from extracellular ATP. Thomas, C., Sun, Y., Naus, K., Lloyd, A., Roux, S. Plant Physiol. (1999) [Pubmed]
  16. Binding of the extracellular matrix component entactin to Candida albicans. López-Ribot, J.L., Chaffin, W.L. Infect. Immun. (1994) [Pubmed]
  17. Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-3-3 proteins. Garcia-Guzman, M., Dolfi, F., Russello, M., Vuori, K. J. Biol. Chem. (1999) [Pubmed]
  18. Purification and partial characterization of a Paracoccidioides brasiliensis protein with capacity to bind to extracellular matrix proteins. González, A., Gómez, B.L., Diez, S., Hernández, O., Restrepo, A., Hamilton, A.J., Cano, L.E. Infect. Immun. (2005) [Pubmed]
  19. Influence of sub-inhibitory concentrations of conventional antifungals on metabolism of Candida albicans and on its adherence to polystyrene and extracellular matrix proteins. Imbert, C., Rodier, M.H., Daniault, G., Jacquemin, J.L. Med. Mycol. (2002) [Pubmed]
  20. KTR2: a new member of the KRE2 mannosyltransferase gene family. Lussier, M., Camirand, A., Sdicu, A.M., Bussey, H. Yeast (1993) [Pubmed]
  21. Bud10p directs axial cell polarization in budding yeast and resembles a transmembrane receptor. Halme, A., Michelitch, M., Mitchell, E.L., Chant, J. Curr. Biol. (1996) [Pubmed]
  22. Immunofluorescence and flow cytometry analysis of fibronectin and laminin binding to Sporothrix schenckii yeast cells and conidia. Lima, O.C., Bouchara, J.P., Renier, G., Marot-Leblond, A., Chabasse, D., Lopes-Bezerra, L.M. Microb. Pathog. (2004) [Pubmed]
  23. Recognition of extracellular matrix proteins by Paracoccidioides brasiliensis yeast cells. Gonzalez, A., Gomez, B.L., Restrepo, A., Hamilton, A.J., Cano, L.E. Med. Mycol. (2005) [Pubmed]
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