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Gene Review:

WSC2 - Wsc2p

Saccharomyces cerevisiae S288c

Synonyms: Cell wall integrity and stress response component 2, N0583, YNL283C

de la Fuente, N. et al., Verna, J. et al., Raboy, B. et al., Zu, T. et al.

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Disease relevance of WSC2

The genes WSC1, WSC2 and WSC3 encode putative receptors that maintain cell wall integrity under conditions of heat stress [1].

High impact information on WSC2

Overexpression of WSC2 reverses the heat-induced cell cycle arrest of rad6-149 but not of rad6 null mutants [2].
Deletion of WSC1 causes a cell lysis defect that is exacerbated by deleting WSC2 or WSC3 [3].
In a genetic screening for multicopy suppressors of the rsp5 mutation, we identified the WSC2/YNL283c gene [4].
Deletion of the WSC2 gene disturbs ATPase activation by glucose, abolishing the K(m) decrease that occurs during this process [4].
Wsc2 is a component of the PKC1-MPK1 mitogen-activated protein kinase (MAPK) signaling pathway that controls the cell wall integrity [4].

Anatomical context of WSC2

The cell wall and stress response component (Wsc) protein family in the yeast Saccharomyces cerevisiae is encoded by at least three genes, WSC1, WSC2, and WSC3 [3].

Other interactions of WSC2

Heat-induced cell cycle arrest of Saccharomyces cerevisiae: involvement of the RAD6/UBC2 and WSC2 genes in its reversal [2].

References

Mutations in WSC genes for putative stress receptors result in sensitivity to multiple stress conditions and impairment of Rlm1-dependent gene expression in Saccharomyces cerevisiae. Zu, T., Verna, J., Ballester, R. Mol. Genet. Genomics (2001) [Pubmed]
Heat-induced cell cycle arrest of Saccharomyces cerevisiae: involvement of the RAD6/UBC2 and WSC2 genes in its reversal. Raboy, B., Marom, A., Dor, Y., Kulka, R.G. Mol. Microbiol. (1999) [Pubmed]
A novel role for the mating type (MAT) locus in the maintenance of cell wall integrity in Saccharomyces cerevisiae. Verna, J., Ballester, R. Mol. Gen. Genet. (1999) [Pubmed]
The cell wall integrity/remodeling MAPK cascade is involved in glucose activation of the yeast plasma membrane H(+)-ATPase. de la Fuente, N., Portillo, F. Biochim. Biophys. Acta (2000) [Pubmed]

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