Gene Review:
NKD1 - naked cuticle homolog 1 (Drosophila)
Homo sapiens
Synonyms:
NKD, Naked-1, PP7246, Protein naked cuticle homolog 1, hNkd, ...
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Disease relevance of NKD1
- NKD1 was up-regulated in colorectal cancer cell line SW480, gastric cancer cell line TMK1, and pancreatic cancer cell line Hs700T [1].
High impact information on NKD1
- NKD1 was highly expressed in fetal kidney, while NKD2 was moderately expressed in fetal kidney, lung, and adult lung [1].
- The NH2 domain of NKD1 and NKD2 contained the EF-hand motif [1].
- NKD1 and NKD2 were up-regulated together in 1 case of primary gastric cancer out of 10 cases, and were down-regulated together in 2 cases [1].
- Up-regulation of NKD1 or NKD2 might be due to a negative feed-back mechanism [1].
- Exon-intron structures of NKD1 and NKD2 genes, consisting of 10 exons, were well conserved [1].
Associations of NKD1 with chemical compounds
- NKD1 and NKD2, showing 43.8% total amino-acid identity, were more homologous in the NH1, NH2, NH3, and NH4 domains [1].
Analytical, diagnostic and therapeutic context of NKD1
- Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2 [1].
References
- Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2. Katoh, M. Int. J. Oncol. (2001) [Pubmed]
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