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Gene Review

NKD2  -  naked cuticle homolog 2 (Drosophila)

Homo sapiens

Synonyms: Naked-2, Naked2, Protein naked cuticle homolog 2, hNkd2
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Disease relevance of NKD2


High impact information on NKD2

  • Detailed nonparametric multidimensional scaling analysis further showed that the expression of TRIO, IRX2, and NKD2 strongly correlated with the gene copy number [1].
  • NKD1 was highly expressed in fetal kidney, while NKD2 was moderately expressed in fetal kidney, lung, and adult lung [2].
  • The NH2 domain of NKD1 and NKD2 contained the EF-hand motif [2].

Biological context of NKD2


Associations of NKD2 with chemical compounds

  • NKD1 and NKD2, showing 43.8% total amino-acid identity, were more homologous in the NH1, NH2, NH3, and NH4 domains [2].

Analytical, diagnostic and therapeutic context of NKD2


  1. Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas. Adamowicz, M., Radlwimmer, B., Rieker, R.J., Mertens, D., Schwarzbach, M., Schraml, P., Benner, A., Lichter, P., Mechtersheimer, G., Joos, S. Genes Chromosomes Cancer (2006) [Pubmed]
  2. Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2. Katoh, M. Int. J. Oncol. (2001) [Pubmed]
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