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Gene Review:

NKD2 - naked cuticle homolog 2 (Drosophila)

Homo sapiens

Synonyms: Naked-2, Naked2, Protein naked cuticle homolog 2, hNkd2

Katoh, M., Adamowicz, M. et al.

Katoh,

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Disease relevance of NKD2

Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas [1].
Of these, TRIO, coding for a guanidine nucleotide exchange factor, was consistently overexpressed in all cases, while IRX2 and NKD2, both involved in the regulation of developmental processes via the WNT pathway, showed a characteristic expression only in MPNSTs [1].
NKD2 was up-regulated in gastric cancer cell line MKN45, pancreatic cancer cell line BxPC-3, and esophageal cancer cell lines TE6, and TE13 [2].

High impact information on NKD2

Detailed nonparametric multidimensional scaling analysis further showed that the expression of TRIO, IRX2, and NKD2 strongly correlated with the gene copy number [1].
NKD1 was highly expressed in fetal kidney, while NKD2 was moderately expressed in fetal kidney, lung, and adult lung [2].
The NH2 domain of NKD1 and NKD2 contained the EF-hand motif [2].

Biological context of NKD2

Up-regulation of NKD1 or NKD2 might be due to a negative feed-back mechanism [2].
Exon-intron structures of NKD1 and NKD2 genes, consisting of 10 exons, were well conserved [2].

Associations of NKD2 with chemical compounds

NKD1 and NKD2, showing 43.8% total amino-acid identity, were more homologous in the NH1, NH2, NH3, and NH4 domains [2].

Analytical, diagnostic and therapeutic context of NKD2

Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2 [2].

References

Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas. Adamowicz, M., Radlwimmer, B., Rieker, R.J., Mertens, D., Schwarzbach, M., Schraml, P., Benner, A., Lichter, P., Mechtersheimer, G., Joos, S. Genes Chromosomes Cancer (2006) [Pubmed]
Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2. Katoh, M. Int. J. Oncol. (2001) [Pubmed]

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NKD2	Bos taurus
NKD2	Canis lupus familiaris
nkd2b	Danio rerio
NKD2	Macaca mulatta
Nkd2	Mus musculus
NKD2	Pan troglodytes
Nkd2	Rattus norvegicus

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