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Gene Review

CRT10  -  Crt10p

Saccharomyces cerevisiae S288c

Synonyms: Constitutive RNR transcription regulator 10, Protein CRT10, YOL063C
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High impact information on CRT10

  • Interestingly, the expression of CRT10 itself is induced by DNA damaging agents and this induction requires DUN1, suggesting that CRT10 plays a role in cellular response to DNA damage and replication blocks [1].
  • Epistatic analysis indicates that CRT10 belongs to the CRT1 pathway but not the SML1 pathway [1].
  • The CRT10 gene was identified through screening of the Saccharomyces cerevisiae deletion library for hydroxyurea (HU) resistance [1].
  • CRT10 encodes a putative 957 amino acid, 110 kDa protein with a leucine repeat and a WD40 repeat near the N-terminus [1].

Biological context of CRT10


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