Gene Review:
SML1 - Sml1p
Saccharomyces cerevisiae S288c
Synonyms:
Ribonucleotide reductase inhibitor protein SML1, YM9958.04, YML058W
- A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Zhao, X., Muller, E.G., Rothstein, R. Mol. Cell (1998)
- The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage. Zhao, X., Chabes, A., Domkin, V., Thelander, L., Rothstein, R. EMBO J. (2001)
- Mutational and structural analyses of the ribonucleotide reductase inhibitor Sml1 define its Rnr1 interaction domain whose inactivation allows suppression of mec1 and rad53 lethality. Zhao, X., Georgieva, B., Chabes, A., Domkin, V., Ippel, J.H., Schleucher, J., Wijmenga, S., Thelander, L., Rothstein, R. Mol. Cell. Biol. (2000)
- Sml1p is a dimer in solution: characterization of denaturation and renaturation of recombinant Sml1p. Gupta, V., Peterson, C.B., Dice, L.T., Uchiki, T., Racca, J., Guo, J.T., Xu, Y., Hettich, R., Zhao, X., Rothstein, R., Dealwis, C.G. Biochemistry (2004)
- The deubiquitinating enzyme Doa4p protects cells from DNA topoisomerase I poisons. Fiorani, P., Reid, R.J., Schepis, A., Jacquiau, H.R., Guo, H., Thimmaiah, P., Benedetti, P., Bjornsti, M.A. J. Biol. Chem. (2004)
- Identification and characterization of CRT10 as a novel regulator of Saccharomyces cerevisiae ribonucleotide reductase genes. Fu, Y., Xiao, W. Nucleic Acids Res. (2006)
- Photochemical surface mapping of C14S-Sml1p for constrained computational modeling of protein structure. Sharp, J.S., Guo, J.T., Uchiki, T., Xu, Y., Dealwis, C., Hettich, R.L. Anal. Biochem. (2005)
- Characterization of monomeric and dimeric forms of recombinant Sml1p-histag protein by electrospray mass spectrometry. Uchiki, T., Hettich, R., Gupta, V., Dealwis, C. Anal. Biochem. (2002)
- The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1. Zhao, X., Rothstein, R. Proc. Natl. Acad. Sci. U.S.A. (2002)
- DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex. Mulder, K.W., Winkler, G.S., Timmers, H.T. Nucleic Acids Res. (2005)
- The conserved Mec1/Rad53 nuclear checkpoint pathway regulates mitochondrial DNA copy number in Saccharomyces cerevisiae. Taylor, S.D., Zhang, H., Eaton, J.S., Rodeheffer, M.S., Lebedeva, M.A., O'rourke, T.W., Siede, W., Shadel, G.S. Mol. Biol. Cell (2005)
- Identification of phosphorylation sites on the yeast ribonucleotide reductase inhibitor Sml1. Uchiki, T., Dice, L.T., Hettich, R.L., Dealwis, C. J. Biol. Chem. (2004)