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Gene Review

PEX15  -  Pex15p

Saccharomyces cerevisiae S288c

Synonyms: PAS21, Peroxin-15, Peroxisomal membrane protein PEX15, Peroxisome biosynthesis protein PAS21, YOL044W
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High impact information on PEX15

  • Even Pex15p requires Pex3p and Pex19p for localization to peroxisomal membranes [1].
  • We provide evidence that ER-accumulated Pex15p is not a sorting intermediate on its way to peroxisomes [1].
  • These results indicate that Pex15p may be targeted to peroxisomes via the ER, or to both organelles [2].
  • We could demonstrate that the N-terminal part of Pex6p contains the binding site for Pex15p and that the two AAA cassettes D1 and D2 of Pex6p have opposite effects on this interaction [3].
  • Pex15p of Saccharomyces cerevisiae provides a molecular basis for recruitment of the AAA peroxin Pex6p to peroxisomal membranes [3].

Biological context of PEX15

  • We have cloned PEX15 which is required for peroxisome biogenesis in Saccharomyces cerevisiae. pex15Delta cells are characterized by the cytosolic accumulation of peroxisomal matrix proteins containing a PTS1 or PTS2 import signal, whereas peroxisomal membrane proteins are present in peroxisomal remnants [2].

Anatomical context of PEX15

  • The lumenal carboxy-terminal tail of Pex15p protrudes into the lumen of these ER membranes, as demonstrated by its O-glycosylation [2].
  • Overexpression of Pex15p resulted in impaired peroxisome assembly, and caused profound proliferation of the endoplasmic reticulum (ER) membrane [2].

Associations of PEX15 with chemical compounds

  • Analysis of the yeast tail-anchored protein Pex15p revealed that it also harbors a luminal PEX19-binding site that acts as a peroxisomal-targeting motif [4].

Other interactions of PEX15

  • Pex15p provides the mechanistic basis for the reversible targeting of Pex6p to peroxisomal membranes [3].


  1. Saccharomyces cerevisiae pex3p and pex19p are required for proper localization and stability of peroxisomal membrane proteins. Hettema, E.H., Girzalsky, W., van Den Berg, M., Erdmann, R., Distel, B. EMBO J. (2000) [Pubmed]
  2. Overexpression of Pex15p, a phosphorylated peroxisomal integral membrane protein required for peroxisome assembly in S.cerevisiae, causes proliferation of the endoplasmic reticulum membrane. Elgersma, Y., Kwast, L., van den Berg, M., Snyder, W.B., Distel, B., Subramani, S., Tabak, H.F. EMBO J. (1997) [Pubmed]
  3. Pex15p of Saccharomyces cerevisiae provides a molecular basis for recruitment of the AAA peroxin Pex6p to peroxisomal membranes. Birschmann, I., Stroobants, A.K., van den Berg, M., Schäfer, A., Rosenkranz, K., Kunau, W.H., Tabak, H.F. Mol. Biol. Cell (2003) [Pubmed]
  4. Targeting of the tail-anchored peroxisomal membrane proteins PEX26 and PEX15 occurs through C-terminal PEX19-binding sites. Halbach, A., Landgraf, C., Lorenzen, S., Rosenkranz, K., Volkmer-Engert, R., Erdmann, R., Rottensteiner, H. J. Cell. Sci. (2006) [Pubmed]
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