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Gene Review

SHE4  -  She4p

Saccharomyces cerevisiae S288c

Synonyms: OR26.26, SWI5-dependent HO expression protein 4, YOR035C
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High impact information on SHE4

  • The CRO1 protein exhibits significant similarity to the SHE4 protein, which is required for asymmetric mating-type switching in budding yeast cells [1].
  • CRO1 and She4p are fungal proteins required for the segregation of other molecules in budding, endocytosis, and septation [2].
  • The UNC-45 protein is predicted to contain an NH2-terminal domain with three tetratricopeptide repeat motifs, a unique central region, and a COOH-terminal domain homologous to CRO1 and She4p [2].
  • This new screening strategy demonstrates a role for She4p and Pan1p in endocytosis, and provides a new general method for the identification of additional endocytosis mutants [3].
  • In a variety of organisms, a novel group of proteins forming the UCS (UNC-45/CRO1/SHE4) domain-containing family are essential for proper myosin function [4].

Biological context of SHE4


Physical interactions of SHE4


Regulatory relationships of SHE4


Other interactions of SHE4

  • Two-hybrid and biochemical experiments showed that She4p/Dim1p interacts with the motor domain of Myo3/5p through its UCS domain [5].
  • Our results suggest that She4p/Dim1p is required for structural integrity or regulation of the motor domain of unconventional myosins [5].


  1. A homologue of the yeast SHE4 gene is essential for the transition between the syncytial and cellular stages during sexual reproduction of the fungus Podospora anserina. Berteaux-Lecellier, V., Zickler, D., Debuchy, R., Panvier-Adoutte, A., Thompson-Coffe, C., Picard, M. EMBO J. (1998) [Pubmed]
  2. Unc-45 mutations in Caenorhabditis elegans implicate a CRO1/She4p-like domain in myosin assembly. Barral, J.M., Bauer, C.C., Ortiz, I., Epstein, H.F. J. Cell Biol. (1998) [Pubmed]
  3. A novel fluorescence-activated cell sorter-based screen for yeast endocytosis mutants identifies a yeast homologue of mammalian eps15. Wendland, B., McCaffery, J.M., Xiao, Q., Emr, S.D. J. Cell Biol. (1996) [Pubmed]
  4. The UCS domain protein She4p binds to myosin motor domains and is essential for class I and class V myosin function. Wesche, S., Arnold, M., Jansen, R.P. Curr. Biol. (2003) [Pubmed]
  5. She4p/Dim1p interacts with the motor domain of unconventional myosins in the budding yeast, Saccharomyces cerevisiae. Toi, H., Fujimura-Kamada, K., Irie, K., Takai, Y., Todo, S., Tanaka, K. Mol. Biol. Cell (2003) [Pubmed]
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