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Gene Review

MYO5  -  myosin 5

Saccharomyces cerevisiae S288c

Synonyms: Actin-dependent myosin-I MYO5, Class I unconventional myosin MYO5, Myosin-5, Type I myosin MYO5, YM9718.08, ...
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High impact information on MYO5

  • Deletion of the genes MYO3 and MYO5, which encode the yeast type I myosins, almost abolished growth [1].
  • A double-deleted mutant complemented with a MYO5 temperature-sensitive allele (myo5-1) showed a strong defect in the internalization step of receptor-mediated endocytosis, whereas the secretory pathway remained apparently unaffected [1].
  • Consistent with this, Myo5p patches assemble but do not localize to sites of polarized cell surface growth in a VRP1 deletion mutant [2].
  • Moreover, incubation of yeast cells at 37 degrees C results in transient depolarization of both Myo5p patches and the actin cytoskeleton [2].
  • Immunolocalization of the myc-tagged SH3 domain of Myo5p reveals diffuse cytoplasmic staining [2].

Biological context of MYO5


Anatomical context of MYO5

  • Mutations in the budding yeast myosins-I (MYO3 and MYO5) cause defects in the actin cytoskeleton and in the endocytic uptake [4].
  • The peak of Myo5 association with cortical patches immediately precedes the fast movement of Arp2/3 complex-associated structures away from the plasma membrane, thus correlating precisely with the proposed vesicle scission event [5].

Associations of MYO5 with chemical compounds

  • We find that latrunculin-A-induced depolymerization of F-actin results in loss of Myo5p patches [2].

Regulatory relationships of MYO5

  • Consistently, we have recently demonstrated, using fluorescence microscopy, that Myo5p is able to induce cytosol-dependent actin polymerization on the surface of Sepharose beads [4].
  • In vitro, She4p stimulates binding of Myo5p to filamentous actin [6].

Other interactions of MYO5


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