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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CKB2  -  casein kinase 2 regulatory subunit CKB2

Saccharomyces cerevisiae S288c

Synonyms: CK II beta', Casein kinase II subunit beta', OR26.32, YOR039W
 
 
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High impact information on CKB2

  • We show that one mutation resides in CDC5, which encodes a polo-like kinase, whereas a second, less penetrant, adaptation-defective mutant is affected at the CKB2 locus, which encodes a nonessential specificity subunit of casein kinase II [1].
  • The deduced amino acid sequence of Ckb2 displays only 40-45% identity to other beta-subunit sequences reported to date, allowing a better definition of conserved features of this protein [2].
  • Haploid and homozygous diploid cells harboring a ckb2 null allele are viable, demonstrating that the beta'-subunit does not have an essential function distinct from that of beta [2].
  • In CKB1/CKB2 double knock-outs, transcription of 54 genes was specifically altered [3].
 

Other interactions of CKB2

References

  1. CDC5 and CKII control adaptation to the yeast DNA damage checkpoint. Toczyski, D.P., Galgoczy, D.J., Hartwell, L.H. Cell (1997) [Pubmed]
  2. Cloning and disruption of CKB2, the gene encoding the 32-kDa regulatory beta'-subunit of Saccharomyces cerevisiae casein kinase II. Reed, J.C., Bidwai, A.P., Glover, C.V. J. Biol. Chem. (1994) [Pubmed]
  3. Genes targeted by protein kinase CK2: a genome-wide expression array analysis in yeast. Ackermann, K., Waxmann, A., Glover, C.V., Pyerin, W. Mol. Cell. Biochem. (2001) [Pubmed]
  4. Transcriptional regulation of the S. cerevisiae ENA1 gene by casein kinase II. Tenney, K.A., Glover, C.V. Mol. Cell. Biochem. (1999) [Pubmed]
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