The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Csnk2b  -  casein kinase 2, beta polypeptide

Rattus norvegicus

Synonyms: CK II beta, Casein kinase II subunit beta, Ck2n, Phosvitin
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Csnk2b

  • Seryl/threonyl-protein kinases in cytosolic and particulate fractions from rat liver and AH-13, a rat ascites hepatoma, have been studied by chromatographing these fractions on DEAE-cellulose and assaying the eluates with casein, phosvitin, histone and protamine as substrates [1].
  • Effects of phosvitin on the ecg changes induced under hypoxia in the rat [2].

High impact information on Csnk2b


Biological context of Csnk2b


Anatomical context of Csnk2b

  • Chromosomal phosvitin kinase strongly increased during the last days of fetal life; it strongly decreased just after birth and increased again for a short time, while the cytosol phosvitin kinase increased more significantly after birth [12].
  • Rat dentin gamma-carboxyglutamate-containing protein of the osteocalcin type (Gla-protein), proteoglycan (PG), and phosphoprotein (PP-H), as well as phosvitin (PhV) and bovine serum albumin (BSA), were covalently linked to agarose beads [13].
  • Reconstituted type I collagen as well as sheet collagen were crosslinked in the presence of alkaline phosphatase and egg-yolk phosvitin [14].
  • Several phosphoprotein preparations (phosvitin, rat incisor and fetal calf molar dentin phosphoproteins) all inhibit apatite growth/replication from pre-existing crystal seeds in metastable solutions [15].
  • Cyclic nucleotide-independent protein kinases that preferentially phosphorylated casein and phosvitin as substrate were detected in the nuclei of human and porcine thyroid tissues, and compared with those from rat liver [16].

Associations of Csnk2b with chemical compounds


Other interactions of Csnk2b


Analytical, diagnostic and therapeutic context of Csnk2b

  • Following FPLC/Superose 6 size exclusion chromatography of PvP1 and PvP2, single peaks of phosvitin phosphatase activities were eluted in the range of 160-220 kDa with acidic pH optima [24].
  • Mineral formation, as monitored by scanning electron microscopy (SEM), was induced by all immobilized polyanions, including enzymatically dephosphorylated PP-H and PhV [13].
  • Both cytosol and mitochondria of rat liver display protein kinase activity, cyclic AMP-independent, which is resolved by Sepharose 6B filtration and P-cellulose chromatography into multiple forms phosphorylating, besides endogenous mitochondrial membrane-bound proteins, also exogenous phosphoproteins such as casein and phosvitin [25].


  1. Casein and histone kinases of a rat ascites hepatoma as compared with those of rat liver. Kikuchi, K., Hirai, R., Mitsui, H., Kiuchi, Y., Tsuiki, S. Jpn. J. Cancer Res. (1985) [Pubmed]
  2. Effects of phosvitin on the ecg changes induced under hypoxia in the rat. Caprino, L., Falchetti, R., Borrelli, F. J. Pharm. Pharmacol. (1976) [Pubmed]
  3. Characterization of protein phosphorylation of the cytosol of AH-66 hepatoma ascites cells. Nakaya, K., Shimizu, T., Segawa, Y., Nakajo, S., Nakamura, Y. Cancer Res. (1983) [Pubmed]
  4. Insulin and ribosomal protein S6 kinase in rat pancreatic acini. Sung, C.K., Williams, J.A. Diabetes (1989) [Pubmed]
  5. In vivo effects of dexamethasone and cycloheximide on the phosphorylation of 110-kDa proteins and the protein kinase activities of rat liver nucleoli. Suzuki, N., Saito, T., Hosoya, T. J. Biol. Chem. (1987) [Pubmed]
  6. Cyclic nucleotide-independent protein kinase from rat liver. Purification and characterization of a multifunctional protein kinase. Ramakrishna, S., Benjamin, W.B. J. Biol. Chem. (1985) [Pubmed]
  7. Effect of starvation, diabetes and insulin on the casein kinase 2 from rat liver cytosol. Martos, C., Plana, M., Guasch, M.D., Itarte, E. Biochem. J. (1985) [Pubmed]
  8. Purification and properties of cyclic AMP-dependent protein kinase from rat epididymis. Biswas, R., Majumder, G.C. J. Reprod. Fertil. (1982) [Pubmed]
  9. Characterization of cationic acid phosphatase isozyme from rat liver mitochondria. Fujimoto, S., Murakami, K., Hosoda, T., Yamamoto, Y., Watanabe, K., Morinaka, Y., Ohara, A. Chem. Pharm. Bull. (1992) [Pubmed]
  10. Interaction of aluminum ions with phosvitin. Geladopoulos, T.P., Sotiroudis, T.G. J. Inorg. Biochem. (1994) [Pubmed]
  11. Structural requirements for the enzymatic phosphorylation of phosvitin. Pinna, L.A., Donella, A., Clari, G., Moret, V. Biochim. Biophys. Acta (1975) [Pubmed]
  12. Hepatocyte chromosomal non-histone proteins in developing rats. Guguen-Guillouzo, C., Tichonicky, L., Kruh, J. Eur. J. Biochem. (1979) [Pubmed]
  13. Mineral induction by immobilized polyanionic proteins. Linde, A., Lussi, A., Crenshaw, M.A. Calcif. Tissue Int. (1989) [Pubmed]
  14. Formation of apatite-collagen complexes. Doi, Y., Horiguchi, T., Moriwaki, Y., Kitago, H., Kajimoto, T., Iwayama, Y. J. Biomed. Mater. Res. (1996) [Pubmed]
  15. Phosphoprotein modulation of apatite crystallization. Termine, J.D., Eanes, E.D., Conn, K.M. Calcif. Tissue Int. (1980) [Pubmed]
  16. Occurrence of protein kinases NI and NII in human and porcine thyroids. Inaba, M., Hamada, N., Yamakawa, J., Ito, K., Morii, H., Yukioka, M., Morisawa, S., Inoue, A. Arch. Biochem. Biophys. (1984) [Pubmed]
  17. Beryllium toxicity. The selective inhibition of casein kinase 1. Cummings, B., Kaser, M.R., Wiggins, G., Ord, M.G., Stocken, L.A. Biochem. J. (1982) [Pubmed]
  18. Polyamines alter the substrate preference of nuclear protein kinase NII. Hara, T., Endo, H. Biochemistry (1982) [Pubmed]
  19. Two classes of dentin phosphophoryns, from a wide range of species, contain immunologically cross-reactive epitope regions. Rahima, M., Veis, A. Calcif. Tissue Int. (1988) [Pubmed]
  20. Nuclear protein kinases of GH3 cells. Fabbro, D., Jungmann, R.A., Eppenberger, U. Horm. Res. (1981) [Pubmed]
  21. Activation of S6 kinase activity in astrocytes by insulin, somatomedin C and TPA. Pierre, M., Toru-Delbauffe, D., Gavaret, J.M., Pomerance, M., Jacquemin, C. FEBS Lett. (1986) [Pubmed]
  22. Purification of nuclear cAMP-independent protein kinases from rat ventral prostate. Goueli, S.A., Davis, A.T., Ahmed, K. Int. J. Biochem. (1986) [Pubmed]
  23. The effects of phosphoproteins on collagen self-assembly in tail tendon and incision dentin from rats. Gelman, R.A., Conn, K.M., Termine, J.D. Biochim. Biophys. Acta (1980) [Pubmed]
  24. Partial purification and characterization of two phosvitin phosphatases from rat brain. Geladopoulos, T.P., Sotiroudis, T.G., Evangelopoulos, A.E. Int. J. Biochem. Cell Biol. (1996) [Pubmed]
  25. Comparative study of mitochondrial and cytosol protein kinase activities. Clari, G., Pinna, L.A., Moret, V. Biochim. Biophys. Acta (1976) [Pubmed]
WikiGenes - Universities