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Gene Review

UBP2  -  Ubp2p

Saccharomyces cerevisiae S288c

Synonyms: Deubiquitinating enzyme 2, O3281, Ubiquitin carboxyl-terminal hydrolase 2, Ubiquitin thioesterase 2, Ubiquitin-specific-processing protease 2, ...
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Disease relevance of UBP2

  • However, both Ubp1 and Ubp2 are also capable of cleaving poly-Ub when coexpressed with it in E. coli, suggesting that such cleavage is largely cotranslational [1].

High impact information on UBP2


Biological context of UBP2


Other interactions of UBP2

  • Both were efficiently Lys(63)-polyubiquitinated by Rsp5 and deubiquitinated by Ubp2 [5].
  • This is supported by the fact that over-expression of the ubiquitin-specific protease Ubp2, which cleaves ubiquitin from its branched conjugates, inhibits this activation [6].


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