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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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RET1  -  DNA-directed RNA polymerase III core...

Saccharomyces cerevisiae S288c

Synonyms: C128, DNA-directed RNA polymerase III 130 kDa polypeptide, DNA-directed RNA polymerase III subunit RPC2, PDS2, RNA polymerase III subunit C2, ...
 
 
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High impact information on RET1

  • Using as the reporter gene a mutant SUP4-o tRNA gene that in one case terminates prematurely and in the other case fails to terminate, we screened mutagenized RET1 libraries for reduced and increased transcription termination, respectively [1].
  • The PTP2 gene is closely linked to the yeast RET1 and STE4 genes and is localized on the right arm of chromosome 15 [2].
  • The RET1 gene was mapped to near the HIS3 gene on the right arm of chromosome 15 by using hybridization to OFAGE gels [3].
  • We have cloned the RET1 gene by complementation of an ochre suppression phenotype in ret1-1 cells [3].
  • Inhibition by anti-C128 or anti-C23 was relieved by preincubation of enzyme C with plasmid DNA prior to antibody addition [4].
 

Regulatory relationships of RET1

  • Overexpression of Pmr1p suppressed some ret1 mutant phenotypes, namely, Ca2+ dependence and enhanced uPA secretion [5].
 

Analytical, diagnostic and therapeutic context of RET1

References

  1. Termination-altering mutations in the second-largest subunit of yeast RNA polymerase III. Shaaban, S.A., Krupp, B.M., Hall, B.D. Mol. Cell. Biol. (1995) [Pubmed]
  2. Isolation and characterization of a second protein tyrosine phosphatase gene, PTP2, from Saccharomyces cerevisiae. Guan, K., Deschenes, R.J., Dixon, J.E. J. Biol. Chem. (1992) [Pubmed]
  3. The RET1 gene of yeast encodes the second-largest subunit of RNA polymerase III. Structural analysis of the wild-type and ret1-1 mutant alleles. James, P., Whelen, S., Hall, B.D. J. Biol. Chem. (1991) [Pubmed]
  4. Yeast RNA polymerase C and its subunits. Specific antibodies as structural and functional probes. Huet, J., Riva, M., Sentenac, A., Fromageot, P. J. Biol. Chem. (1985) [Pubmed]
  5. C-terminal truncation of alpha-COP affects functioning of secretory organelles and calcium homeostasis in Hansenula polymorpha. Chechenova, M.B., Romanova, N.V., Deev, A.V., Packeiser, A.N., Smirnov, V.N., Agaphonov, M.O., Ter-Avanesyan, M.D. Eukaryotic Cell (2004) [Pubmed]
  6. RNA polymerase III defects suppress a conditional-lethal poly(A) polymerase mutation in Saccharomyces cerevisiae. Briggs, M.W., Butler, J.S. Genetics (1996) [Pubmed]
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