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Gene Review

RET1  -  DNA-directed RNA polymerase III core...

Saccharomyces cerevisiae S288c

Synonyms: C128, DNA-directed RNA polymerase III 130 kDa polypeptide, DNA-directed RNA polymerase III subunit RPC2, PDS2, RNA polymerase III subunit C2, ...
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High impact information on RET1

  • Using as the reporter gene a mutant SUP4-o tRNA gene that in one case terminates prematurely and in the other case fails to terminate, we screened mutagenized RET1 libraries for reduced and increased transcription termination, respectively [1].
  • The PTP2 gene is closely linked to the yeast RET1 and STE4 genes and is localized on the right arm of chromosome 15 [2].
  • The RET1 gene was mapped to near the HIS3 gene on the right arm of chromosome 15 by using hybridization to OFAGE gels [3].
  • We have cloned the RET1 gene by complementation of an ochre suppression phenotype in ret1-1 cells [3].
  • Inhibition by anti-C128 or anti-C23 was relieved by preincubation of enzyme C with plasmid DNA prior to antibody addition [4].

Regulatory relationships of RET1

  • Overexpression of Pmr1p suppressed some ret1 mutant phenotypes, namely, Ca2+ dependence and enhanced uPA secretion [5].

Analytical, diagnostic and therapeutic context of RET1


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