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Gene Review

PTP2  -  Ptp2p

Saccharomyces cerevisiae S288c

Synonyms: PTPase 2, Protein-tyrosine phosphatase 2, Tyrosine-protein phosphatase 2, YOR208W
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Disease relevance of PTP2


High impact information on PTP2

  • Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hog1 MAP kinase in yeast [2].
  • In contrast, disruption of PTP3 in combination with its homolog PTP2 results in constitutive tyrosine phosphorylation, enhanced kinase activity of Fus3p MAP kinase on stimulation, and delayed recovery from the cell cycle arrest [3].
  • In addition, deletion of PTP2, but not PTP3, exacerbated growth defects due to MKK1-386 [4].
  • In vivo and in vitro evidence indicates that both PTPs inactivate Mpk1, but Ptp2 is the more effective negative regulator [4].
  • Here we report that deletion of PTP2 and PTP3 results in a sporulation defect, suggesting that tyrosine phosphorylation is involved in regulation of meiosis and sporulation [5].

Biological context of PTP2


Anatomical context of PTP2


Associations of PTP2 with chemical compounds

  • Two genes encoding protein-tyrosine phosphatases, PTP2, and a new phosphatase, PTP3, have been isolated in a genetic selection for negative regulators of an osmotic stress response pathway called HOG, for high osmolarity glycerol, in budding yeast [8].
  • Phosphatase activity is required for suppression since mutation of the catalytic Cys residue in Ptp2 and Ptp3, destroys suppressor function and biochemical activity [8].

Enzymatic interactions of PTP2

  • Disruption of PTP2 leads to elevated levels of tyrosine-phosphorylated Hog1p following exposure of cells to high osmolarity [9].

Other interactions of PTP2

  • Deletion of PTP2 and PTP3 blocks cells at an early stage of sporulation before premeiotic DNA synthesis and induction of meiotic-specific genes [5].
  • We also observed that expression of the PTP2 tyrosine phosphatase gene (a negative regulator of the osmosensing MAP kinase cascade), but not the PTP1 gene (also encoding a tyrosine phosphatase) was induced by nitrogen-starvation [10].
  • The S. cerevisiae nitrogen starvation-induced Yvh1p and Ptp2p phosphatases play a role in control of sporulation [10].
  • Thus, Ptp2p and Ptp3p are the major phosphatases responsible for the tyrosine dephosphorylation of Hog1p [9].
  • Moreover, hyperactivation of Hog1p by deletion of protein phosphatase PTP2 enhanced the response, while blocking the pathway by deletion of the MAPKK PBS2 had a negative effect [11].


  1. Heat stress activates the yeast high-osmolarity glycerol mitogen-activated protein kinase pathway, and protein tyrosine phosphatases are essential under heat stress. Winkler, A., Arkind, C., Mattison, C.P., Burkholder, A., Knoche, K., Ota, I. Eukaryotic Cell (2002) [Pubmed]
  2. Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hog1 MAP kinase in yeast. Mattison, C.P., Ota, I.M. Genes Dev. (2000) [Pubmed]
  3. Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiae. Zhan, X.L., Deschenes, R.J., Guan, K.L. Genes Dev. (1997) [Pubmed]
  4. Differential regulation of the cell wall integrity mitogen-activated protein kinase pathway in budding yeast by the protein tyrosine phosphatases Ptp2 and Ptp3. Mattison, C.P., Spencer, S.S., Kresge, K.A., Lee, J., Ota, I.M. Mol. Cell. Biol. (1999) [Pubmed]
  5. Essential functions of protein tyrosine phosphatases PTP2 and PTP3 and RIM11 tyrosine phosphorylation in Saccharomyces cerevisiae meiosis and sporulation. Zhan, X.L., Hong, Y., Zhu, T., Mitchell, A.P., Deschenes, R.J., Guan, K.L. Mol. Biol. Cell (2000) [Pubmed]
  6. Isolation and characterization of a second protein tyrosine phosphatase gene, PTP2, from Saccharomyces cerevisiae. Guan, K., Deschenes, R.J., Dixon, J.E. J. Biol. Chem. (1992) [Pubmed]
  7. Multiple protein tyrosine phosphatase-encoding genes in the yeast Saccharomyces cerevisiae. James, P., Hall, B.D., Whelen, S., Craig, E.A. Gene (1992) [Pubmed]
  8. Two protein-tyrosine phosphatases inactivate the osmotic stress response pathway in yeast by targeting the mitogen-activated protein kinase, Hog1. Jacoby, T., Flanagan, H., Faykin, A., Seto, A.G., Mattison, C., Ota, I. J. Biol. Chem. (1997) [Pubmed]
  9. Regulation of the Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatases. Wurgler-Murphy, S.M., Maeda, T., Witten, E.A., Saito, H. Mol. Cell. Biol. (1997) [Pubmed]
  10. The S. cerevisiae nitrogen starvation-induced Yvh1p and Ptp2p phosphatases play a role in control of sporulation. Park, H.D., Beeser, A.E., Clancy, M.J., Cooper, T.G. Yeast (1996) [Pubmed]
  11. The HOG MAP kinase pathway is required for the induction of methylglyoxal-responsive genes and determines methylglyoxal resistance in Saccharomyces cerevisiae. Aguilera, J., Rodríguez-Vargas, S., Prieto, J.A. Mol. Microbiol. (2005) [Pubmed]
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