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Gene Review

SAS5  -  Sas5p

Saccharomyces cerevisiae S288c

Synonyms: Something about silencing protein 5, YOR213C
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Disease relevance of SAS5

  • Similarly, SAS5 is a member of a gene family that included two human genes that are the sites of recurring translocations involved in acute myeloid leukemia [1].
  • Yaf9, Taf14, and Sas5 comprise the YEATS domain family in Saccharomyces cerevisiae, which in humans includes proteins involved in acute leukemias [2].

High impact information on SAS5

  • Here we identify a ~450-kD SAS complex containing Sas2p, Sas4p, and the tf2f-related Sas5 protein [3].
  • Sas2 forms a complex with Sas4 and Sas5, which are required for its silencing function [4].
  • An unknown signal region was located in the N-terminal domain of Sas5p and was responsible for the nuclear import by Kap123p and Pse1p [5].

Other interactions of SAS5

  • Collectively, these data suggest that SAS2, SAS4, and SAS5 constitute a novel class of regulators of silencing and reveal fundamental differences in the regulation of silencing at HML and HMR [6].
  • Neither SAS4 nor SAS5 was required for viability [1].


  1. Identification of SAS4 and SAS5, two genes that regulate silencing in Saccharomyces cerevisiae. Xu, E.Y., Kim, S., Replogle, K., Rine, J., Rivier, D.H. Genetics (1999) [Pubmed]
  2. The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Zhang, H., Richardson, D.O., Roberts, D.N., Utley, R., Erdjument-Bromage, H., Tempst, P., Côté, J., Cairns, B.R. Mol. Cell. Biol. (2004) [Pubmed]
  3. The yeast SAS (something about silencing) protein complex contains a MYST-type putative acetyltransferase and functions with chromatin assembly factor ASF1. Osada, S., Sutton, A., Muster, N., Brown, C.E., Yates, J.R., Sternglanz, R., Workman, J.L. Genes Dev. (2001) [Pubmed]
  4. Sas4 and Sas5 are required for the histone acetyltransferase activity of Sas2 in the SAS complex. Sutton, A., Shia, W.J., Band, D., Kaufman, P.D., Osada, S., Workman, J.L., Sternglanz, R. J. Biol. Chem. (2003) [Pubmed]
  5. Nuclear import of the histone acetyltransferase complex SAS-I in Saccharomyces cerevisiae. Schaper, S., Franke, J., Meijsing, S.H., Ehrenhofer-Murray, A.E. J. Cell. Sci. (2005) [Pubmed]
  6. SAS4 and SAS5 are locus-specific regulators of silencing in Saccharomyces cerevisiae. Xu, E.Y., Kim, S., Rivier, D.H. Genetics (1999) [Pubmed]
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