The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

YAF9  -  Yaf9p

Saccharomyces cerevisiae S288c

Synonyms: N1966, Protein AF-9 homolog, YNL107W
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on YAF9


Biological context of YAF9


Anatomical context of YAF9

  • Interference with Swc4p function also increases sensitivity to the microtubule toxin benomyl, a trait that corresponds to the known phenotype of a yaf9(-) knockout strain [4].

Physical interactions of YAF9

  • Here, we demonstrate that Yaf9p binds directly to Swc4p, the yeast homolog of the mammalian DNA-methyltransferase-associated protein 1 [4].

Other interactions of YAF9

  • The bromodomain-containing protein Bdf1p acts as a phenotypic and transcriptional multicopy suppressor of YAF9 deletion in yeast [3].

Analytical, diagnostic and therapeutic context of YAF9


  1. The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Zhang, H., Richardson, D.O., Roberts, D.N., Utley, R., Erdjument-Bromage, H., Tempst, P., Côté, J., Cairns, B.R. Mol. Cell. Biol. (2004) [Pubmed]
  2. Yaf9, a novel NuA4 histone acetyltransferase subunit, is required for the cellular response to spindle stress in yeast. Le Masson, I., Yu, D.Y., Jensen, K., Chevalier, A., Courbeyrette, R., Boulard, Y., Smith, M.M., Mann, C. Mol. Cell. Biol. (2003) [Pubmed]
  3. The bromodomain-containing protein Bdf1p acts as a phenotypic and transcriptional multicopy suppressor of YAF9 deletion in yeast. Bianchi, M.M., Costanzo, G., Chelstowska, A., Grabowska, D., Mazzoni, C., Piccinni, E., Cavalli, A., Ciceroni, F., Rytka, J., Slonimski, P.P., Frontali, L., Negri, R. Mol. Microbiol. (2004) [Pubmed]
  4. Direct physical and functional interaction of the NuA4 complex components Yaf9p and Swc4p. Bittner, C.B., Zeisig, D.T., Zeisig, B.B., Slany, R.K. Eukaryotic Cell (2004) [Pubmed]
WikiGenes - Universities