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Gene Review

RPB8  -  DNA-directed RNA polymerase core subunit RPB8

Saccharomyces cerevisiae S288c

Synonyms: ABC14.4, ABC14.5, DNA-directed RNA polymerases I, II, and III 14.5 kDa polypeptide, DNA-directed RNA polymerases I, II, and III subunit RPABC3, RNA polymerases I, II, and III subunit ABC3, ...
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High impact information on RPB8

  • RPB5 encodes a 25-kD protein, RPB6, an 18-kD protein, and RPB8, a 16-kD protein [1].
  • The Saccharomyces cerevisiae genes that encode these subunits (RPB5, RPB6, and RPB8) were isolated and sequenced, and their transcriptional start sites were deduced [1].
  • The gene for this subunit is present in single copy and maps to chromosome XV, where two other yeast RNA polymerase II subunits, RPB2 and RPB8, reside [2].
  • In Saccharomyces cerevisiae, ABC14.5 (Rpb8) is essential for cell viability, however its function remains unknown [3].

Other interactions of RPB8

  • Hence, Rpb6p and Rpb8p functionally interact in vivo [4].


  1. Subunits shared by eukaryotic nuclear RNA polymerases. Woychik, N.A., Liao, S.M., Kolodziej, P.A., Young, R.A. Genes Dev. (1990) [Pubmed]
  2. RNA polymerase II subunit RPB10 is essential for yeast cell viability. Woychik, N.A., Young, R.A. J. Biol. Chem. (1990) [Pubmed]
  3. Sequence divergence of the RNA polymerase shared subunit ABC14.5 (Rpb8) selectively affects RNA polymerase III assembly in Saccharomyces cerevisiae. Voutsina, A., Riva, M., Carles, C., Alexandraki, D. Nucleic Acids Res. (1999) [Pubmed]
  4. Partners of Rpb8p, a small subunit shared by yeast RNA polymerases I, II and III. Briand, J.F., Navarro, F., Rematier, P., Boschiero, C., Labarre, S., Werner, M., Shpakovski, G.V., Thuriaux, P. Mol. Cell. Biol. (2001) [Pubmed]
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