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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

WTM2  -  Wtm2p

Saccharomyces cerevisiae S288c

Synonyms: Transcriptional modulator WTM2, YOR229W, YOR50-19
 
 
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High impact information on WTM2

  • These data suggested that Wtm1p and Wtm2p are repressors and that Wtm3p has different effects on transcription at different loci [1].
  • This protein has two homologs, Wtm2p and Wtm3p, which probably arose by gene duplications [1].
  • Moderate overexpression of both genes together, or high-level expression of WTM2 alone from a constitutive promoter, upregulates RNR3-lacZ in the absence of DNA damage [2].
 

Biological context of WTM2

  • From this screen we isolated a plasmid encoding two closely related paralogs, WTM1 and WTM2, that greatly increases constitutive expression of RNR3-lacZ [2].
  • Further investigation reveals that Wtm2p and Wtm1p, previously described as regulators of meiotic gene expression and transcriptional silencing, amplify transcriptional induction of RNR3 in response to replication stress and modulate expression of genes encoding other RNR subunits [2].

References

  1. Characterization of the Wtm proteins, a novel family of Saccharomyces cerevisiae transcriptional modulators with roles in meiotic regulation and silencing. Pemberton, L.F., Blobel, G. Mol. Cell. Biol. (1997) [Pubmed]
  2. The WTM Genes in Budding Yeast Amplify Expression of the Stress-Inducible Gene RNR3. Tringe, S.G., Willis, J., Liberatore, K.L., Ruby, S.W. Genetics (2006) [Pubmed]
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