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Gene Review

UME1  -  Ume1p

Saccharomyces cerevisiae S288c

Synonyms: LPI7C, Transcriptional regulatory protein UME1, WD repeat-containing transcriptional modulator 3, WTM3, YPL139C
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High impact information on UME1

  • We show by co-immunoprecipitation and by the high similarity of their binding maps that Ume1 interacts with Rpd3 [1].
  • In contrast, mutations in five previously identified UME loci (UME1 to UME5), result in low to moderate derepression (2- to 10-fold increase) of early meiotic genes [2].
  • Wtm3p did not appear to be complexed with the other two proteins, was essential for IME2 repression, and could not efficiently repress transcription in the absence of the other Wtm proteins [3].
  • This protein has two homologs, Wtm2p and Wtm3p, which probably arose by gene duplications [3].
  • In addition, these results suggest that Rpd3-Ume1p-Sin3p comprises an interdependent complex required for mediating transcriptional repression [4].

Biological context of UME1

  • In addition to mitotic cell division, this report describes a new role for Ume1p in meiotic gene repression in precommitment sporulating cultures returning to vegetative growth [4].

Regulatory relationships of UME1


  1. Genome-wide binding map of the histone deacetylase Rpd3 in yeast. Kurdistani, S.K., Robyr, D., Tavazoie, S., Grunstein, M. Nat. Genet. (2002) [Pubmed]
  2. UME6 is a key regulator of nitrogen repression and meiotic development. Strich, R., Surosky, R.T., Steber, C., Dubois, E., Messenguy, F., Esposito, R.E. Genes Dev. (1994) [Pubmed]
  3. Characterization of the Wtm proteins, a novel family of Saccharomyces cerevisiae transcriptional modulators with roles in meiotic regulation and silencing. Pemberton, L.F., Blobel, G. Mol. Cell. Biol. (1997) [Pubmed]
  4. Ume1p represses meiotic gene transcription in Saccharomyces cerevisiae through interaction with the histone deacetylase Rpd3p. Mallory, M.J., Strich, R. J. Biol. Chem. (2003) [Pubmed]
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