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Gene Review

MPH1  -  Mph1p

Saccharomyces cerevisiae S288c

Synonyms: ATP-dependent DNA helicase MPH1, FANCM-like protein 1, Mutator phenotype protein 1, YIB2C, YIR002C
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High impact information on MPH1

  • Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicase [1].
  • Further studies showed that MPH1 functions to channel DNA lesions into an error-free DNA repair pathway [1].
  • The MPH1 (mutator pHenotype 1) gene of Saccharomyces cerevisiae was identified on the basis of elevated spontaneous mutation rates of haploid cells deleted for this gene [1].
  • Genetic analyses have found epistasis of the mph1 deletion with mutations in the RAD52 gene group that mediates homologous recombination and DNA repair by homologous recombination [1].
  • We present data to demonstrate that the Mph1 DNA helicase activity is fueled by ATP hydrolysis and has a 3' to 5' polarity with respect to the DNA strand on which this protein translocates [1].

Biological context of MPH1


Other interactions of MPH1

  • This approach led to the identification of several candidates, including a putative transcription factor, Azf1p, and Mph1p, a protein with an RNA helicase domain which is known to influence the mutation rate of nuclear and mitochondrial genomes [3].


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