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Gene Review

MET28  -  Met28p

Saccharomyces cerevisiae S288c

Synonyms: Methionine-requiring protein 28, Transcriptional activator of sulfur metabolism MET28, YIR017C
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High impact information on MET28

  • Situated upstream of the sulfur genes, this element is the binding site of a transcription activation complex consisting of a basic helix-loop-helix factor, Cbf1p, and two basic leucine zipper factors, Met4p and Met28p [1].
  • Molecular studies have unraveled the specific functions for each subunit of the Cbf1p-Met4p-Met28p complex as well as the modalities of its assembly on the DNA [1].
  • We also demonstrate that Met28 possesses no intrinsic transcription activation capabilities [2].
  • Our results give evidence that the leucine zippers of Met4 and Met28, along with the basic helix-loop-helix domain of Cbf1, provide the protein surfaces mediating these interactions [2].
  • Here we report the downstream regulatory subnetworks for UME6 and MET28 [3].

Biological context of MET28


Physical interactions of MET28

  • Moreover, Met28 is shown to enhance the DNA-binding activity of Cbf1 [4].

Other interactions of MET28

  • In this paper, we demonstrate that other pathways are used to recruit Met4p on the 5' upstream region of the two genes, MET3 and MET28 [5].

Analytical, diagnostic and therapeutic context of MET28


  1. Metabolism of sulfur amino acids in Saccharomyces cerevisiae. Thomas, D., Surdin-Kerjan, Y. Microbiol. Mol. Biol. Rev. (1997) [Pubmed]
  2. A heteromeric complex containing the centromere binding factor 1 and two basic leucine zipper factors, Met4 and Met28, mediates the transcription activation of yeast sulfur metabolism. Kuras, L., Cherest, H., Surdin-Kerjan, Y., Thomas, D. EMBO J. (1996) [Pubmed]
  3. Discovery of novel transcription control relationships with gene regulatory networks generated from multiple-disruption full genome expression libraries. Aburatani, S., Tashiro, K., Savoie, C.J., Nishizawa, M., Hayashi, K., Ito, Y., Muta, S., Yamamoto, K., Ogawa, M., Enomoto, A., Masaki, M., Watanabe, S., Maki, Y., Takahashi, Y., Eguchi, Y., Sakaki, Y., Kuhara, S. DNA Res. (2003) [Pubmed]
  4. Assembly of a bZIP-bHLH transcription activation complex: formation of the yeast Cbf1-Met4-Met28 complex is regulated through Met28 stimulation of Cbf1 DNA binding. Kuras, L., Barbey, R., Thomas, D. EMBO J. (1997) [Pubmed]
  5. Multiple transcriptional activation complexes tether the yeast activator Met4 to DNA. Blaiseau, P.L., Thomas, D. EMBO J. (1998) [Pubmed]
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