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Gene Review: 

SEC65  -  Sec65p

Saccharomyces cerevisiae S288c

Synonyms: Signal recognition particle subunit SEC65, YM8339.14C, YML105C
 
 
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High impact information on SEC65

  • The DNA sequence of the SEC65 gene suggests that its product is related to mammalian SRP19 subunit and may have a similar function [1].
  • Here we show that SEC65p is a subunit of the S. cerevisiae SRP and that it is required for the stable association of another subunit, SRP54p, with SRP [1].
  • As a first step toward identifying cell components important in folding of the nascent ATPase, we have used the dual assays to examine the role of KAR2, encoding the yeast homolog of immunoglobulin heavy chain binding protein/78-kDa glucose-regulated protein, and SEC65, encoding a subunit of the yeast signal recognition particle [2].
  • Temperature-sensitive lethal mutations defining two complementation groups have been isolated: a new allele of sec61 and a single isolate of a new gene sec65 [3].
  • Deletion of the YlSEC65 gene is lethal, in contrast with the results described for the Saccharomyces cerevisiae SEC65 gene, which is not essential for cell growth and whose deletion results in slowly growing strains [4].
 

Anatomical context of SEC65

References

  1. SEC65 gene product is a subunit of the yeast signal recognition particle required for its integrity. Hann, B.C., Stirling, C.J., Walter, P. Nature (1992) [Pubmed]
  2. Folding and intracellular transport of the yeast plasma-membrane H(+)-ATPase: effects of mutations in KAR2 and SEC65. Chang, A., Rose, M.D., Slayman, C.W. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  3. Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum. Stirling, C.J., Rothblatt, J., Hosobuchi, M., Deshaies, R., Schekman, R. Mol. Biol. Cell (1992) [Pubmed]
  4. Isolation and cloning of the Yarrowia lipolytica SEC65 gene, a component of the yeast signal recognition particle displaying homology with the human SRP19 gene. Sánchez, M., Beckerich, J.M., Gaillardin, C., Domínguez, A. Gene (1997) [Pubmed]
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