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RLF2  -  Rlf2p

Saccharomyces cerevisiae S288c

Synonyms: CAC1, CAF-1 90 kDa subunit, Chromatin assembly factor 1 subunit p90, RAP1 localization factor 2, YP9531.12, ...
 
 
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Disease relevance of RLF2

 

High impact information on RLF2

 

Biological context of RLF2

  • Saccharomyces cerevisiae mutants lacking CAF-I subunit genes (CAC1 to CAC3) display reduced heterochromatic gene silencing [5].
  • Single-cell analysis revealed that individual cac1 delta cells switch from transcriptionally "off" to transcriptionally "on" more often per cell cycle than wild-type cells [6].
  • In addition, cac1 delta cells were defective for transcriptional silencing near internal tracts of C(1-3)A sequence, but they showed no defect in silencing at the silent mating type loci when analyzed by a reverse transcription-PCR assay [6].
  • We investigated this mechanism and found that CAC3 suppression of RAS/cAMP signal transduction was independent of either CAC1 or CAC2, subunits required for CAF-I function [7].
  • Deletion of CAC1 also increased the UV sensitivity and rate of UV-induced mutagenesis in rad5Delta mutants, as has been observed for mutants defective in error-free postreplicative repair [8].
 

Anatomical context of RLF2

  • Although cac1 delta cells could establish and maintain transcriptional repression at telomeres, they displayed a reduced heritability of the repressed state [6].
 

Other interactions of RLF2

  • Amongst 24 interacting clones isolated in a two-hybrid screening, seven could be identified as parts of the RAD2, RLF2 and DBR1 genes [9].
 

Analytical, diagnostic and therapeutic context of RLF2

References

  1. Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans. Alspaugh, J.A., Pukkila-Worley, R., Harashima, T., Cavallo, L.M., Funnell, D., Cox, G.M., Perfect, J.R., Kronstad, J.W., Heitman, J. Eukaryotic Cell (2002) [Pubmed]
  2. The budding yeast silencing protein Sir1 is a functional component of centromeric chromatin. Sharp, J.A., Krawitz, D.C., Gardner, K.A., Fox, C.A., Kaufman, P.D. Genes Dev. (2003) [Pubmed]
  3. Chromatin assembly factor I contributes to the maintenance, but not the re-establishment, of silencing at the yeast silent mating loci. Enomoto, S., Berman, J. Genes Dev. (1998) [Pubmed]
  4. RLF2, a subunit of yeast chromatin assembly factor-I, is required for telomeric chromatin function in vivo. Enomoto, S., McCune-Zierath, P.D., Gerami-Nejad, M., Sanders, M.A., Berman, J. Genes Dev. (1997) [Pubmed]
  5. Chromatin assembly factor I mutants defective for PCNA binding require Asf1/Hir proteins for silencing. Krawitz, D.C., Kama, T., Kaufman, P.D. Mol. Cell. Biol. (2002) [Pubmed]
  6. The yeast Cac1 protein is required for the stable inheritance of transcriptionally repressed chromatin at telomeres. Monson, E.K., de Bruin, D., Zakian, V.A. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  7. CAC3(MSI1) suppression of RAS2(G19V) is independent of chromatin assembly factor I and mediated by NPR1. Johnston, S.D., Enomoto, S., Schneper, L., McClellan, M.C., Twu, F., Montgomery, N.D., Haney, S.A., Broach, J.R., Berman, J. Mol. Cell. Biol. (2001) [Pubmed]
  8. Role of Saccharomyces cerevisiae chromatin assembly factor-I in repair of ultraviolet radiation damage in vivo. Game, J.C., Kaufman, P.D. Genetics (1999) [Pubmed]
  9. Thermoconditional modulation of the pleiotropic sensitivity phenotype by the Saccharomyces cerevisiae PRP19 mutant allele pso4-1. Revers, L.F., Cardone, J.M., Bonatto, D., Saffi, J., Grey, M., Feldmann, H., Brendel, M., Henriques, J.A. Nucleic Acids Res. (2002) [Pubmed]
 
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