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Gene Review

RRB1  -  Rrb1p

Saccharomyces cerevisiae S288c

Synonyms: Ribosome assembly protein RRB1, YM9553.07C, YMR131C
 
 
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High impact information on RRB1

  • We also showed that overexpression of RRB1 led to an increase in the expression of RPL3 while all other examined RP genes were unaffected [1].
  • Using a yeast CIN indicator strain, we show that inactivation of the YMR131c/RRB1 gene, which is involved in early ribosome assembly and whose expression is induced when the spindle checkpoint is activated, alters chromosome segregation and blocks mitosis at the metaphase/anaphase transition [2].

References

  1. Rrb1p, a yeast nuclear WD-repeat protein involved in the regulation of ribosome biosynthesis. Iouk, T.L., Aitchison, J.D., Maguire, S., Wozniak, R.W. Mol. Cell. Biol. (2001) [Pubmed]
  2. Inactivation of the RRB1-Pescadillo pathway involved in ribosome biogenesis induces chromosomal instability. Killian, A., Le Meur, N., Sesboüé, R., Bourguignon, J., Bougeard, G., Gautherot, J., Bastard, C., Frébourg, T., Flaman, J.M. Oncogene (2004) [Pubmed]
 
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