The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

CAF40  -  CCR4-NOT core subunit CAF40

Saccharomyces cerevisiae S288c

Synonyms: 40 kDa CCR4-associated factor, N0540, Protein CAF40, YNL288W
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on CAF40

  • The distinct location of CAF40 and CAF130 and the evolutionary conservation of CAF40 implicate them in novel roles in the function of the CCR4-NOT complex [1].
  • Rcd-1, a protein highly conserved across eukaryotes, was initially identified as a factor essential for nitrogen starvation-invoked differentiation in fission yeast, and its Saccharomyces cerevisiae homolog, CAF40, has been identified as part of the CCR4-NOT transcription complex, where it interacts with the NOT1 protein [2].
 

Biological context of CAF40

  • Analysis of caf40 and caf130 deletions indicated that they elicited phenotypes shared by defects in other CCR4-NOT genes [1].
 

Analytical, diagnostic and therapeutic context of CAF40

References

  1. Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex. Chen, J., Rappsilber, J., Chiang, Y.C., Russell, P., Mann, M., Denis, C.L. J. Mol. Biol. (2001) [Pubmed]
  2. Atomic model of human Rcd-1 reveals an armadillo-like-repeat protein with in vitro nucleic acid binding properties. Garces, R.G., Gillon, W., Pai, E.F. Protein Sci. (2007) [Pubmed]
 
WikiGenes - Universities