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Gene Review

RQCD1  -  RCD1 required for cell differentiation1...

Homo sapiens

Synonyms: CCR4-NOT transcription complex subunit 9, CNOT9, CT129, Cell differentiation protein RCD1 homolog, RCD-1, ...
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Disease relevance of RQCD1

  • Here we show that mammalian Rcd1 is a novel transcriptional cofactor and is critically involved in the commitment step in the retinoic acid-induced differentiation of F9 mouse teratocarcinoma cells, at least in part, via forming complexes with retinoic acid receptor and activation transcription factor-2 (ATF-2) [1].

High impact information on RQCD1

  • In addition, antisense oligonucleotide treatment of embryonic mouse lung explants suggests that Rcd1 also plays a role in retinoic acid-controlled lung development [1].
  • Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation [1].
  • Cells with rcd1+ deleted are sterile if sexual development is induced by nitrogen starvation but fertile if it is induced by glucose starvation [2].


  1. Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation. Hiroi, N., Ito, T., Yamamoto, H., Ochiya, T., Jinno, S., Okayama, H. EMBO J. (2002) [Pubmed]
  2. Novel factor highly conserved among eukaryotes controls sexual development in fission yeast. Okazaki, N., Okazaki, K., Watanabe, Y., Kato-Hayashi, M., Yamamoto, M., Okayama, H. Mol. Cell. Biol. (1998) [Pubmed]
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