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Gene Review

RHO5  -  Rho family GTPase RHO5

Saccharomyces cerevisiae S288c

Synonyms: GTP-binding protein RHO5, N1644, YNL180C
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High impact information on RHO5

  • Kinetics of actin depolarisation and repolarisation after heat treatment of rho5 deletions as well as strains overexpressing the activated RHO5Q91H allele provide further evidence for such a function [1].
  • We conclude that Rho5p acts as an off-switch for the MAP-kinase cascade, which differentiates between MAP-kinase-dependent and -independent functions of Pkc1p [1].
  • Here we show that a rho5 deletion results in an increased activity of the protein kinase C (Pkc1p)-dependent signal transduction pathway [1].
  • With the exception of Rho5p, these enzymes have been assigned different biological functions, including the regulation of polar growth, morphogenesis, actin cytoskeleton, budding and secretion [1].
  • In addition, we brought the first evidence for the existence of a sixth functional Rho in yeast, the Cdc42/Rac-like GTPase Rho5 [2].


  1. Rho5p downregulates the yeast cell integrity pathway. Schmitz, H.P., Huppert, S., Lorberg, A., Heinisch, J.J. J. Cell. Sci. (2002) [Pubmed]
  2. Functional characterization of the Bag7, Lrg1 and Rgd2 RhoGAP proteins from Saccharomyces cerevisiae. Roumanie, O., Weinachter, C., Larrieu, I., Crouzet, M., Doignon, F. FEBS Lett. (2001) [Pubmed]
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