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Gene Review

SPC98  -  Spc98p

Saccharomyces cerevisiae S288c

Synonyms: N1222, N1879, Spindle pole body component SPC98, YNL126W
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Disease relevance of SPC98


High impact information on SPC98

  • The yeast Xgrip109 homologue, Spc98, is a spindle-pole body component that interacts with gamma tubulin [2].
  • Primers derived from the human expressed sequence tag matching SPC98 were used to clone the 5' and 3' cDNA ends by rapid amplification of cDNA ends (RACE)-PCR [3].
  • The human Spc98 cDNA presents an alternative splicing at the 3' end [3].
  • Strong overexpression of SPC98 is toxic, causing cells to arrest with a large bud, defective microtubule structures, undivided nucleus and replicated DNA [1].

Biological context of SPC98

  • Evidence is provided for a physical and functional interaction between Tub4p, Spc98p and Spc97p: first, temperature-sensitive spc97(ts) mutants are suppressed by high gene dosage of SPC98 or TUB4 [4].

Anatomical context of SPC98


Physical interactions of SPC98


Other interactions of SPC98

  • The screen identified mutations in SPC97 and SPC98, two genes encoding components of the Tub4p complex in yeast [5].


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