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Gene Review

RPC19  -  DNA-directed RNA polymerase core subunit...

Saccharomyces cerevisiae S288c

Synonyms: AC19, DNA-directed RNA polymerases I and III 16 kDa polypeptide, DNA-directed RNA polymerases I and III subunit RPAC2, N1937, RNA polymerases I and III subunit AC2, ...
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High impact information on RPC19

  • Polyclonal antibodies outlined the alpha-like subunit AC40 and subunit AC19 which were found co-localized also in the apical region of the enzyme [1].
  • The deduced amino acid sequence shows 45% identity to the yeast subunit AC19 of RNA polymerases I and III, known to associate with AC40, and a local similarity to bacterial alpha subunit [2].
  • This gene (RPC19) contains an intron-free open reading frame of 143 amino acid residues [3].
  • RPC19 is a single copy gene that maps on chromosome II and is essential for cell viability [3].
  • D also interacts under the same conditions with the RPB11 and AC19 subunits from the yeast Saccharomyces cerevisiae, suggesting that essential elements of the binding surface between these proteins have been conserved across the archaeal/eukaryotic evolutionary domain boundary [4].

Other interactions of RPC19

  • Mutational analysis of the corresponding "alpha motif" indicated that its integrity is essential on AC40 subunit but is not essential on AC19 subunit [5].
  • The association of Gtr1p with Rpc19p occurred in a GTP-form-specific manner [6].
  • Gel-filtration studies revealed an accumulation of the smaller Rpc19p-containing complex, but not of A135, in the gtr1Delta strain [6].


  1. Localization of yeast RNA polymerase I core subunits by immunoelectron microscopy. Klinger, C., Huet, J., Song, D., Petersen, G., Riva, M., Bautz, E.K., Sentenac, A., Oudet, P., Schultz, P. EMBO J. (1996) [Pubmed]
  2. Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa subunit is a homolog of yeast AC19 subunit of RNA polymerases I and III. Yao, Y., Yamamoto, K., Nishi, Y., Nogi, Y., Muramatsu, M. J. Biol. Chem. (1996) [Pubmed]
  3. RPC19, the gene for a subunit common to yeast RNA polymerases A (I) and C (III). Dequard-Chablat, M., Riva, M., Carles, C., Sentenac, A. J. Biol. Chem. (1991) [Pubmed]
  4. In vitro assembly of an archaeal D-L-N RNA polymerase subunit complex reveals a eukaryote-like structural arrangement. Eloranta, J.J., Kato, A., Teng, M.S., Weinzierl, R.O. Nucleic Acids Res. (1998) [Pubmed]
  5. Interactions between three common subunits of yeast RNA polymerases I and III. Lalo, D., Carles, C., Sentenac, A., Thuriaux, P. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  6. Association of the GTP-binding protein Gtr1p with Rpc19p, a shared subunit of RNA polymerase I and III in yeast Saccharomyces cerevisiae. Todaka, Y., Wang, Y., Tashiro, K., Nakashima, N., Nishimoto, T., Sekiguchi, T. Genetics (2005) [Pubmed]
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