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Gene Review:

NST1 - Nst1p

Saccharomyces cerevisiae S288c

Synonyms: N2231, Negatively-affecting salt tolerance protein 1, Stress response protein NST1, YNL091W

Goossens, A. et al.

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High impact information on NST1

Loss of MSL1 and NST1 function has pleiotropic phenotypes including increased sensitivity to divalent cations (manganese and zinc) and to caffeine (a cell wall-weakening agent) [1].
The salt tolerance mechanism of nst1 mutants is novel because it is not related to osmoregulation, altered cation accumulation or sulphate metabolism [1].

Associations of NST1 with chemical compounds

On the other hand, msl1 mutants but not nst1 mutants are sensitive to thiabendazole (a microtubule-destabilizing agent) and to osmotic stress [1].

References

Involvement of Nst1p/YNL091w and Msl1p, a U2B'' splicing factor, in Saccharomyces cerevisiae salt tolerance. Goossens, A., Forment, J., Serrano, R. Yeast (2002) [Pubmed]

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