Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

MSL1 - Msl1p

Saccharomyces cerevisiae S288c

Synonyms: U2 small nuclear ribonucleoprotein B'', U2 snRNP B'', YIB9W, YIR009W

Goossens, A. et al., Copps, K. et al.

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High impact information on MSL1

Using a modified two-hybrid assay, we isolated missense mutations in MSL2 that disrupt its interaction with MSL1 [1].
We focused our analysis on the MSL2-MSL1 interaction, which is postulated to play a critical role in MSL complex association with the X chromosome [1].
Loss of MSL1 and NST1 function has pleiotropic phenotypes including increased sensitivity to divalent cations (manganese and zinc) and to caffeine (a cell wall-weakening agent) [2].

Associations of MSL1 with chemical compounds

On the other hand, msl1 mutants but not nst1 mutants are sensitive to thiabendazole (a microtubule-destabilizing agent) and to osmotic stress [2].

References

Complex formation by the Drosophila MSL proteins: role of the MSL2 RING finger in protein complex assembly. Copps, K., Richman, R., Lyman, L.M., Chang, K.A., Rampersad-Ammons, J., Kuroda, M.I. EMBO J. (1998) [Pubmed]
Involvement of Nst1p/YNL091w and Msl1p, a U2B'' splicing factor, in Saccharomyces cerevisiae salt tolerance. Goossens, A., Forment, J., Serrano, R. Yeast (2002) [Pubmed]

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