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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CTI6  -  Cti6p

Saccharomyces cerevisiae S288c

Synonyms: CYC8-TUP1-interacting protein 6, Histone deacetylase complex subunit CTI6, RXT1, Transcriptional regulatory protein CTI6, YPL181W
 
 
 
 
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High impact information on CTI6

  • To further identify genes that function in iron and copper homeostasis, we screened for novel yeast mutants defective for iron limiting growth and thereby identified the CTI6 gene [1].
  • Furthermore, we demonstrate that Cti6 is a nuclear protein that functionally associates with the Rpd3-Sin3 histone deacetylase complex involved in transcriptional repression [1].
  • Microarray experiments with cti6 mutants grown under iron-limiting conditions show a down-regulation of telomeric genes and an up-regulation of Aft1 and Tup1 target genes involved in iron and oxygen regulation [1].
  • Taken together, these data suggest a specific role for Cti6 in the regulation of gene expression under conditions of iron limitation [1].

References

  1. Cti6 is an Rpd3-Sin3 histone deacetylase-associated protein required for growth under iron-limiting conditions in Saccharomyces cerevisiae. Puig, S., Lau, M., Thiele, D.J. J. Biol. Chem. (2004) [Pubmed]
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