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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NOG1  -  Nog1p

Saccharomyces cerevisiae S288c

Synonyms: LPG15W, Nucleolar GTP-binding protein 1, YPL093W
 
 
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High impact information on NOG1

  • TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients [1].
  • Thus, the Nog1 complex is a critical regulator of ribosome biogenesis mediated by TOR [1].
  • Conditional mutants of both NOG1 and LSG1 are defective in 60S subunit biogenesis and display diminished levels of 60S subunits at restrictive temperature [2].
  • Together these data suggest that NOG1 may play an important role in nucleolar functions [3].
  • The S. cerevisae NOG1 gene is essential for cell viability, and mutations in the predicted G motifs abrogate function [3].

References

  1. TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients. Honma, Y., Kitamura, A., Shioda, R., Maruyama, H., Ozaki, K., Oda, Y., Mini, T., Jenö, P., Maki, Y., Yonezawa, K., Hurt, E., Ueno, M., Uritani, M., Hall, M.N., Ushimaru, T. EMBO J. (2006) [Pubmed]
  2. The putative GTPases Nog1p and Lsg1p are required for 60S ribosomal subunit biogenesis and are localized to the nucleus and cytoplasm, respectively. Kallstrom, G., Hedges, J., Johnson, A. Mol. Cell. Biol. (2003) [Pubmed]
  3. A novel nucleolar G-protein conserved in eukaryotes. Park, J.H., Jensen, B.C., Kifer, C.T., Parsons, M. J. Cell. Sci. (2001) [Pubmed]
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