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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GTPBP4  -  GTP binding protein 4

Homo sapiens

Synonyms: CRFG, Chronic renal failure gene protein, FLJ10686, FLJ10690, GTP-binding protein NGB, ...
 
 
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High impact information on GTPBP4

  • TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients [1].
  • Thus, the Nog1 complex is a critical regulator of ribosome biogenesis mediated by TOR [1].
  • Nucleostemin (NS) encodes a nucleolar GTP-binding protein highly enriched in the stem cells and cancer cells [2].
  • Disruption of NOG1 function through RNA interference led to a dramatic decrease in the levels of free 60 S particles and the appearance of an atypical rRNA intermediate in which ITS2 was not cleaved [3].
  • Cloning, fluorescent tagging and expression in HeLa cells of the putative GTP-binding protein NGB/CRFG demonstrated it to be a novel mitotic chromosome protein, with a perichromosomal localisation [4].

References

  1. TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients. Honma, Y., Kitamura, A., Shioda, R., Maruyama, H., Ozaki, K., Oda, Y., Mini, T., Jenö, P., Maki, Y., Yonezawa, K., Hurt, E., Ueno, M., Uritani, M., Hall, M.N., Ushimaru, T. EMBO J. (2006) [Pubmed]
  2. Nucleostemin Delays Cellular Senescence and Negatively Regulates TRF1 Protein Stability. Zhu, Q., Yasumoto, H., Tsai, R.Y. Mol. Cell. Biol. (2006) [Pubmed]
  3. The NOG1 GTP-binding protein is required for biogenesis of the 60 S ribosomal subunit. Jensen, B.C., Wang, Q., Kifer, C.T., Parsons, M. J. Biol. Chem. (2003) [Pubmed]
  4. Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate. Morrison, C., Henzing, A.J., Jensen, O.N., Osheroff, N., Dodson, H., Kandels-Lewis, S.E., Adams, R.R., Earnshaw, W.C. Nucleic Acids Res. (2002) [Pubmed]
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