The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

YTH1  -  Yth1p

Saccharomyces cerevisiae S288c

Synonyms: YPR107C, Yeast 30 kDa homolog 1, mRNA 3'-end-processing protein YTH1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on YTH1

  • In contrast, the mutation of factors involved in the subsequent polyadenylation step (PAP1, FIP1, and YTH1) had little effect [1].
  • Finally, we find that Yth1p binds to CYC1 pre-mRNA in the vicinity of the cleavage site [2].
  • Distinct roles of two Yth1p domains in 3'-end cleavage and polyadenylation of yeast pre-mRNAs [2].
  • A single point mutation in the highly conserved second zinc finger impairs both cleavage and polyadenylation, and affects the ability of Yth1p to interact with the pre-mRNA and other CPF subunits [2].
  • Here, we demonstrate that Yth1p is also required for the cleavage reaction and that two protein domains have distinct roles in 3'-end processing [2].

Biological context of YTH1


Physical interactions of YTH1

  • We demonstrate that Yth1p is a component of PF I that interacts in vivo and in vitro with Fip1p, a known PF I subunit [4].

Analytical, diagnostic and therapeutic context of YTH1


  1. Coupling termination of transcription to messenger RNA maturation in yeast. Birse, C.E., Minvielle-Sebastia, L., Lee, B.A., Keller, W., Proudfoot, N.J. Science (1998) [Pubmed]
  2. Distinct roles of two Yth1p domains in 3'-end cleavage and polyadenylation of yeast pre-mRNAs. Barabino, S.M., Ohnacker, M., Keller, W. EMBO J. (2000) [Pubmed]
  3. Functional dissection of the zinc finger and flanking domains of the Yth1 cleavage/polyadenylation factor. Tacahashi, Y., Helmling, S., Moore, C.L. Nucleic Acids Res. (2003) [Pubmed]
  4. The 30-kD subunit of mammalian cleavage and polyadenylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins. Barabino, S.M., Hübner, W., Jenny, A., Minvielle-Sebastia, L., Keller, W. Genes Dev. (1997) [Pubmed]
WikiGenes - Universities