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Gene Review

TAZ1  -  Taz1p

Saccharomyces cerevisiae S288c

Synonyms: 1-acylglycerophosphocholine O-acyltransferase, Lysophosphatidylcholine acyltransferase, Tafazzin homolog, YPR140W, lyso-PC acyltransferase
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High impact information on TAZ1


Anatomical context of TAZ1

  • Subcellular fractionation studies revealed that Taz1p is localized exclusively in mitochondria, which supports the theory that tafazzins are involved in cardiolipin remodeling [3].

Associations of TAZ1 with chemical compounds


  1. Mitochondrial mislocalization and altered assembly of a cluster of Barth syndrome mutant tafazzins. Claypool, S.M., McCaffery, J.M., Koehler, C.M. J. Cell Biol. (2006) [Pubmed]
  2. Taz1, an outer mitochondrial membrane protein, affects stability and assembly of inner membrane protein complexes: implications for Barth Syndrome. Brandner, K., Mick, D.U., Frazier, A.E., Taylor, R.D., Meisinger, C., Rehling, P. Mol. Biol. Cell (2005) [Pubmed]
  3. The human TAZ gene complements mitochondrial dysfunction in the yeast taz1Delta mutant. Implications for Barth syndrome. Ma, L., Vaz, F.M., Gu, Z., Wanders, R.J., Greenberg, M.L. J. Biol. Chem. (2004) [Pubmed]
  4. Aberrant cardiolipin metabolism in the yeast taz1 mutant: a model for Barth syndrome. Gu, Z., Valianpour, F., Chen, S., Vaz, F.M., Hakkaart, G.A., Wanders, R.J., Greenberg, M.L. Mol. Microbiol. (2004) [Pubmed]
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