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Gene Review:

TAZ1 - Taz1p

Saccharomyces cerevisiae S288c

Synonyms: 1-acylglycerophosphocholine O-acyltransferase, Lysophosphatidylcholine acyltransferase, Tafazzin homolog, YPR140W, lyso-PC acyltransferase

Brandner, K. et al., Claypool, S.M. et al., Ma, L. et al., Gu, Z. et al.

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High impact information on TAZ1

In this study, endogenous Taz1p was localized to mitochondria in association with both the inner and outer mitochondrial membranes facing the intermembrane space (IMS) [1].
None of the 28 identified point mutations in tafazzin (Taz1p), which is the mutant gene product associated with Barth syndrome (BTHS), has a biochemical explanation [1].
Taz1, an outer mitochondrial membrane protein, affects stability and assembly of inner membrane protein complexes: implications for Barth Syndrome [2].
Taz1 is a mitochondrial acyltransferase involved in the remodeling of cardiolipin [2].
We conclude that inactivation of Taz1 affects both assembly and stability of respiratory chain complexes in the inner membrane of mitochondria [2].

Anatomical context of TAZ1

Subcellular fractionation studies revealed that Taz1p is localized exclusively in mitochondria, which supports the theory that tafazzins are involved in cardiolipin remodeling [3].

Associations of TAZ1 with chemical compounds

Aberrant cardiolipin metabolism in the yeast taz1 mutant: a model for Barth syndrome [4].

References

Mitochondrial mislocalization and altered assembly of a cluster of Barth syndrome mutant tafazzins. Claypool, S.M., McCaffery, J.M., Koehler, C.M. J. Cell Biol. (2006) [Pubmed]
Taz1, an outer mitochondrial membrane protein, affects stability and assembly of inner membrane protein complexes: implications for Barth Syndrome. Brandner, K., Mick, D.U., Frazier, A.E., Taylor, R.D., Meisinger, C., Rehling, P. Mol. Biol. Cell (2005) [Pubmed]
The human TAZ gene complements mitochondrial dysfunction in the yeast taz1Delta mutant. Implications for Barth syndrome. Ma, L., Vaz, F.M., Gu, Z., Wanders, R.J., Greenberg, M.L. J. Biol. Chem. (2004) [Pubmed]
Aberrant cardiolipin metabolism in the yeast taz1 mutant: a model for Barth syndrome. Gu, Z., Valianpour, F., Chen, S., Vaz, F.M., Hakkaart, G.A., Wanders, R.J., Greenberg, M.L. Mol. Microbiol. (2004) [Pubmed]

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AgaP_AGAP007599	Anopheles gambiae str. PEST
AT3G05510	Arabidopsis thaliana
AGOS_AGR254C	Ashbya gossypii ATCC 10895
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acl-3	Caenorhabditis elegans
TAZ	Canis lupus familiaris
taz	Danio rerio
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TAZ	Homo sapiens
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taz	Xenopus (Silurana) tropicalis

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