Disease relevance of taz

• The tafazzin knockdown created by antisense morpholino yolk injection resulted in dose-dependent lethality, severe developmental and growth retardation, marked bradycardia and pericardial effusions, and generalized edema, signs that resemble human Barth syndrome heart failure [1].
• Barth syndrome is an X-linked disorder characterized by cardiomyopathy, skeletal myopathy, neutropenia, organic aciduria, and growth retardation caused by mutations in tafazzin [1].

High impact information on taz

• This knockdown phenotype was rescued by concomitant injection of normal tafazzin mRNA [1].

Analytical, diagnostic and therapeutic context of taz

• The tafazzin knockdown zebrafish provides an animal model similar to Barth syndrome to analyze the severity of human mutants and to test potential treatments [1].

References