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Gene Review

taz  -  tafazzin

Danio rerio

Synonyms: SO:0000704, wu:fb39f12, zgc:91803
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Disease relevance of taz

  • The tafazzin knockdown created by antisense morpholino yolk injection resulted in dose-dependent lethality, severe developmental and growth retardation, marked bradycardia and pericardial effusions, and generalized edema, signs that resemble human Barth syndrome heart failure [1].
  • Barth syndrome is an X-linked disorder characterized by cardiomyopathy, skeletal myopathy, neutropenia, organic aciduria, and growth retardation caused by mutations in tafazzin [1].

High impact information on taz

  • This knockdown phenotype was rescued by concomitant injection of normal tafazzin mRNA [1].

Analytical, diagnostic and therapeutic context of taz

  • The tafazzin knockdown zebrafish provides an animal model similar to Barth syndrome to analyze the severity of human mutants and to test potential treatments [1].


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