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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

OSH7  -  oxysterol-binding protein related protein...

Saccharomyces cerevisiae S288c

Synonyms: Oxysterol-binding protein homolog 7, YHR001W
 
 
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High impact information on OSH7

  • The yeast genome encodes seven oxysterol binding protein homologs, Osh1p-Osh7p, which have been implicated in regulating intracellular lipid and vesicular transport [1].
  • Here, we show that both Osh6p and Osh7p interact with Vps4p, a member of the AAA (ATPases associated with a variety of cellular activities) family [1].
 

Biological context of OSH7

  • To determine the functions of the yeast OSBP gene family (OSH1-OSH7), we used a combination of genetics, genomics, and sterol lipid analysis to characterize OSH deletion mutants [2].
 

Other interactions of OSH7

  • The seven yeast OSH genes (OSH1-OSH7) encode a family of orthologs of the mammalian oxysterol-binding protein (OSBP) [3].
  • Lastly, overexpression of the coiled-coil domain of Osh7p (Osh7pCC) resulted in a multivesicular body sorting defect, suggesting a dominant negative role of Osh7pCC possibly through inhibiting Vps4p function [1].

References

  1. AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism. Wang, P., Zhang, Y., Li, H., Chieu, H.K., Munn, A.L., Yang, H. EMBO J. (2005) [Pubmed]
  2. Overlapping functions of the yeast oxysterol-binding protein homologues. Beh, C.T., Cool, L., Phillips, J., Rine, J. Genetics (2001) [Pubmed]
  3. A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution. Beh, C.T., Rine, J. J. Cell. Sci. (2004) [Pubmed]
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