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Gene Review

LEU5  -  Leu5p

Saccharomyces cerevisiae S288c

Synonyms: Mitochondrial carrier protein LEU5, YHR002W
 
 
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Disease relevance of LEU5

  • Here, we investigated the yeast carrier Leu5p (encoded by the gene YHR002w) and its close human homologue Graves' disease protein [1].
 

High impact information on LEU5

  • Deletion of LEU5 (strain Deltaleu5) was accompanied by a 15-fold reduction of mitochondrial coenzyme A (CoA) levels but did not affect the cytosolic CoA content [1].
  • The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix [1].
  • Our in vitro and in vivo analyses assign a function to Leu5p in the accumulation of CoA in mitochondria, presumably by serving as a transporter of CoA or a precursor thereof [1].
  • This shows that LEU5 is not essential for leucine biosynthesis [2].
  • LEU5 maps to chromosome VIII and is tightly linked to CEN8 [2].
 

Biological context of LEU5

  • Five different mutations in LEU5 were analyzed: a site-directed deletion and a disruption, as well as three distinct mutations produced by chemical mutagenesis [2].
  • In a leu4 background, each leu5 mutation causes a Leu--phenotype; in a LEU4 background, none of the mutations alters the Leu+ phenotype [2].
 

Other interactions of LEU5

  • In either a leu4 or LEU4 background, each leu5 mutation causes a glycerol--phenotype [2].

References

  1. The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix. Prohl, C., Pelzer, W., Diekert, K., Kmita, H., Bedekovics, T., Kispal, G., Lill, R. Mol. Cell. Biol. (2001) [Pubmed]
  2. Yeast LEU5 is a PET-like gene that is not essential for leucine biosynthesis. Drain, P., Schimmel, P. Mol. Gen. Genet. (1986) [Pubmed]
 
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