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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review

RRM3  -  Rrm3p

Saccharomyces cerevisiae S288c

Synonyms: ATP-dependent DNA helicase RRM3, RTT104, Regulation of Ty1 transposition protein 104, YHR031C, rDNA recombination mutation protein 3
 
 
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High impact information on RRM3

  • This slowing was greatly exacerbated in the absence of RRM3, shown here to encode a 5' to 3' DNA helicase [1].
  • In addition, mutating the two phenylalanine residues in the PIP-box to alanine or aspartic acid reduces binding to PCNA, confirming that the PIP-box in RRM3 is responsible for interaction with PCNA [2].
  • A newly identified temperature-sensitive lethal point mutation in RRM 1 is exacerbated by mutations in the U6 RNA telestem, as is a mutation in RRM 2, but not one in RRM 3 [3].
  • This, coupled to our finding that the Rad53p protein kinase is phosphorylated in the rrm3Delta pif1Delta double-mutant strain, leads us to conclude that one mechanism whereby deletion of RRM3 influences mtDNA stability is by modulating mitochondrial deoxynucleoside triphosphate pools [4].
  • In addition, we found that over-expression of RNR1, encoding a large subunit of ribonucleotide reductase (RNR), rescued the petite-induction phenotype of a pif1Delta mutation to a similar extent as deletion of RRM3 [4].
 

Biological context of RRM3

  • Instead, deletion of RRM3 alone resulted in an increase in mtDNA point mutagenesis that was synergistic with that caused by a pif1Delta mutation [4].
 

Other interactions of RRM3

  • Here we show that deletion of the RRM3 gene, which encodes a DNA helicase closely related to Pif1p, significantly rescues the petite-induction phenotype of a pif1Delta strain [4].

References

 
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