The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

LRP1  -  Lrp1p

Saccharomyces cerevisiae S288c

Synonyms: Exosome complex protein LRP1, Like an rRNA processing protein 1, RRP47, YC1D, YHR081W, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on LRP1

  • Two of these factors, mRNA surveillance factor Rrp6 and DNA repair protein Lrp1, are nuclear exosome components that physically interact with one another [1].
  • Further, Rrp6 and Lrp1 are both required for repair of UV-induced DNA damage [1].
  • We find that Lrp1 mediates specific mRNA degradation upon DNA-damaging UV irradiation as well as general mRNA degradation [1].
  • It accumulates at a perinuclear region, and mutations in let-512/vps34 result in an expansion of the outer nuclear membrane as well as in a mislocalization and subsequent complete lack of expression of LRP-1, a C.elegans LDL receptor normally associated with the apical surface of hypodermal cells [2].
  • These results indicate that CeVPS-27 is required for endosomal and autophagic pathways in C. elegans and plays a crucial role in the control of molting through LRP-1 internalization and cholesterol traffic [3].


  1. Genome-wide mRNA surveillance is coupled to mRNA export. Hieronymus, H., Yu, M.C., Silver, P.A. Genes Dev. (2004) [Pubmed]
  2. Membrane transport in Caenorhabditis elegans: an essential role for VPS34 at the nuclear membrane. Roggo, L., Bernard, V., Kovacs, A.L., Rose, A.M., Savoy, F., Zetka, M., Wymann, M.P., Müller, F. EMBO J. (2002) [Pubmed]
  3. CeVPS-27 is an endosomal protein required for the molting and the endocytic trafficking of the low-density lipoprotein receptor-related protein 1 in Caenorhabditis elegans. Roudier, N., Lefebvre, C., Legouis, R. Traffic (2005) [Pubmed]
WikiGenes - Universities