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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SAM35  -  Sam35p

Saccharomyces cerevisiae S288c

Synonyms: FMP20, Mitochondrial 38 kDa outer membrane protein, OMP85, Sorting assembly machinery 35 kDa subunit, TOB complex 38 kDa subunit, ...
 
 
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High impact information on SAM35

  • Here we report two novel mitochondrial outer membrane proteins in yeast, Tom13 and Tom38/Sam35, that mediate assembly of mitochondrial beta-barrel proteins, Tom40, and/or porin in the outer membrane [1].
  • The presence of two essential proteins in the SAM complex, Sam35 and Sam50, indicates that it plays a central role in mitochondrial biogenesis [2].
  • Here we report the identification of Sam35, the first peripheral mitochondrial outer membrane protein that is essential for cell viability [2].
  • Depletion of Tob38 results in strongly reduced levels of Tob55 and Mas37 and the residual proteins no longer form a complex [3].
  • Tob38-depleted mitochondria are deficient in the import of beta-barrel precursor proteins, but not of other outer membrane proteins or proteins of other mitochondrial subcompartments [3].

References

  1. Two novel proteins in the mitochondrial outer membrane mediate beta-barrel protein assembly. Ishikawa, D., Yamamoto, H., Tamura, Y., Moritoh, K., Endo, T. J. Cell Biol. (2004) [Pubmed]
  2. Sam35 of the mitochondrial protein sorting and assembly machinery is a peripheral outer membrane protein essential for cell viability. Milenkovic, D., Kozjak, V., Wiedemann, N., Lohaus, C., Meyer, H.E., Guiard, B., Pfanner, N., Meisinger, C. J. Biol. Chem. (2004) [Pubmed]
  3. Tob38, a novel essential component in the biogenesis of beta-barrel proteins of mitochondria. Waizenegger, T., Habib, S.J., Lech, M., Mokranjac, D., Paschen, S.A., Hell, K., Neupert, W., Rapaport, D. EMBO Rep. (2004) [Pubmed]
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