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Gene Review:

SAM37 - Sam37p

Saccharomyces cerevisiae S288c

Synonyms: MAS37, MAS37 protein, Mitochondrial 37 kDa outer membrane protein, PET3027, Sorting assembly machinery 37 kDa subunit, ...

Armstrong, L.C. et al., Gratzer, S. et al., Waizenegger, T. et al., Kozjak, V. et al., Hachiya, N. et al., et al.

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High impact information on SAM37

We show that the precursor-MSF complex first binds to the Mas37p/Mas70p subunits of the mitochondrial import receptor [1].
Mas37p, a novel receptor subunit for protein import into mitochondria [2].
Hence, the biogenesis of Mas37 represents a novel import pathway of mitochondrial proteins [3].
The assembly pathway of the precursor of Tom40 involves the TOM complex and the sorting and assembly machinery (SAM complex) with the non-essential subunit Mas37 [4].
In its N-terminal region, metaxin shows significant sequence identity to Tom37, a component of the outer membrane portion of the mitochondrial preprotein translocation apparatus in Saccharomyces cerevisiae, but important structural differences, including apparently different mechanisms of targeting to membranes, also exist between the two proteins [5].

Other interactions of SAM37

We suggest that the Mas37p/Mas70p heterodimer functions as a receptor for protein import into yeast mitochondria and that the mitochondrial receptor system consists of hetero-oligomeric subcomplexes with distinct binding activities, but overlapping precursor specificities [2].
Known constituents of this complex are Tob55 and Mas37 [6].
Depletion of Tob38 results in strongly reduced levels of Tob55 and Mas37 and the residual proteins no longer form a complex [6].

References

Reconstitution of the initial steps of mitochondrial protein import. Hachiya, N., Mihara, K., Suda, K., Horst, M., Schatz, G., Lithgow, T. Nature (1995) [Pubmed]
Mas37p, a novel receptor subunit for protein import into mitochondria. Gratzer, S., Lithgow, T., Bauer, R.E., Lamping, E., Paltauf, F., Kohlwein, S.D., Haucke, V., Junne, T., Schatz, G., Horst, M. J. Cell Biol. (1995) [Pubmed]
Assembly of the TOB complex of mitochondria. Habib, S.J., Waizenegger, T., Lech, M., Neupert, W., Rapaport, D. J. Biol. Chem. (2005) [Pubmed]
An essential role of Sam50 in the protein sorting and assembly machinery of the mitochondrial outer membrane. Kozjak, V., Wiedemann, N., Milenkovic, D., Lohaus, C., Meyer, H.E., Guiard, B., Meisinger, C., Pfanner, N. J. Biol. Chem. (2003) [Pubmed]
Metaxin is a component of a preprotein import complex in the outer membrane of the mammalian mitochondrion. Armstrong, L.C., Komiya, T., Bergman, B.E., Mihara, K., Bornstein, P. J. Biol. Chem. (1997) [Pubmed]
Tob38, a novel essential component in the biogenesis of beta-barrel proteins of mitochondria. Waizenegger, T., Habib, S.J., Lech, M., Mokranjac, D., Paschen, S.A., Hell, K., Neupert, W., Rapaport, D. EMBO Rep. (2004) [Pubmed]

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