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Gene Review

KIC1  -  Kic1p

Saccharomyces cerevisiae S288c

Synonyms: Kinase that interacts with CDC31, N-rich kinase 1, NRK1, Serine/threonine-protein kinase KIC1, YHR102W
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High impact information on KIC1

  • These results suggest the existence of a MAPK cascade that consists of NPK1, NQK1/NtMEK1, and NRK1 and functions in a process related to the architecture of phragmoplasts at the late M phase of the cell cycle [1].
  • Both NQK1/NtMEK1 and NRK1, as well as NPK1, are activated at the late M phase of the cell cycle in tobacco cells, and they are rapidly inactivated by depolymerization of phragmoplast microtubules [1].
  • A previously reported cdc31 temperature-sensitive allele, which is neither defective in SPB duplication nor Kic1 kinase activation, induces mRNA export defects [2].
  • Kic1p is closely related to S. cerevisiae Ste20p and the p-21- activated kinases (PAKs) found in a wide variety of eukaryotic organisms [3].
  • Although kic1 mutants were not defective for spindle pole body duplication, they exhibited a variety of mutant phenotypes demonstrating that Kic1p is required for cell integrity [3].

Biological context of KIC1


Anatomical context of KIC1

  • Both over- and underexpressing conditions of KIC1 affected cell wall composition [4].

Associations of KIC1 with chemical compounds

  • We also identified a novel leucine-rich repeat-containing protein Sog2p that interacts with Hym1p and Kic1p [5].

Other interactions of KIC1

  • Interestingly, expression levels of KIC1 and the MAP kinase kinase PBS2 had opposite effects on Zymolyase sensitivity of the cells and on cell wall 1,6-beta-glucan levels in the wall [4].
  • Kic1-deficient cells also became highly resistant to the cell wall-degrading enzyme mixture Zymolyase, and exhibited higher transcript levels of the cell wall protein-encoding genes CWP2 and SED1 [4].
  • Multicopy suppressor analysis of a Kic1-deficient strain identified RHO3 [4].
  • Furthermore, GST-Kic1p exhibited in vitro kinase activity that was CDC31-dependent [3].


  1. NQK1/NtMEK1 is a MAPKK that acts in the NPK1 MAPKKK-mediated MAPK cascade and is required for plant cytokinesis. Soyano, T., Nishihama, R., Morikiyo, K., Ishikawa, M., Machida, Y. Genes Dev. (2003) [Pubmed]
  2. Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery. Fischer, T., Rodríguez-Navarro, S., Pereira, G., Rácz, A., Schiebel, E., Hurt, E. Nat. Cell Biol. (2004) [Pubmed]
  3. The yeast centrin, cdc31p, and the interacting protein kinase, Kic1p, are required for cell integrity. Sullivan, D.S., Biggins, S., Rose, M.D. J. Cell Biol. (1998) [Pubmed]
  4. The protein kinase Kic1 affects 1,6-beta-glucan levels in the cell wall of Saccharomyces cerevisiae. Vink, E., Vossen, J.H., Ram, A.F., van den Ende, H., Brekelmans, S., de Nobel, H., Klis, F.M. Microbiology (Reading, Engl.) (2002) [Pubmed]
  5. RAM: a conserved signaling network that regulates Ace2p transcriptional activity and polarized morphogenesis. Nelson, B., Kurischko, C., Horecka, J., Mody, M., Nair, P., Pratt, L., Zougman, A., McBroom, L.D., Hughes, T.R., Boone, C., Luca, F.C. Mol. Biol. Cell (2003) [Pubmed]
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