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Gene Review

HYM1  -  Hym1p

Saccharomyces cerevisiae S288c

Synonyms: Protein HYM1, YKL189W
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High impact information on HYM1

  • CBK1 and another gene, HYM1, were previously identified in a screen for genes involved in transcriptional repression and proposed to function in the same pathway [1].
  • We also identified a novel leucine-rich repeat-containing protein Sog2p that interacts with Hym1p and Kic1p [2].
  • Furthermore, the budding yeast MO25 homologue, Hym1, is important for cell separation and morphogenesis [3].
  • Finally, our findings suggest that Hym1p requires the Dcr2p phosphatase to promote the G1/S transition, but it does not require the G1 cyclin Cln3p or the RAS pathway [4].
  • Our results suggest opposing roles of RAM proteins, where only Hym1p can promote the transition from the G1 to S phase of the cell cycle [4].

Biological context of HYM1

  • Deletion of HYM1 causes phenotypes similar to those observed in cbk1Delta cells and disrupts the bud neck localization of Cbk1p [1].
  • Here, we report that increased dosage of HYM1 apparently shortens the G1 phase of the cell cycle [5].
  • Genetic analysis of HYM1, ACE2 and CLN3 mutants suggests that these genes together contribute to the establishment of asynchronous mother-daughter cell divisions, but probably not in a linear pathway [5].
  • Our overall data suggest that Hym1p has a regulatory role in cell cycle progression [5].

Regulatory relationships of HYM1

  • In yeast, Hym1p plays a role in cellular morphogenesis and also promotes the daughter cell-specific localization of the Ace2p transcription factor [5].

Other interactions of HYM1

  • In the absence of HYM1 or ACE2, mother and daughter cells divide with the same generation times [5].


  1. The Cbk1p pathway is important for polarized cell growth and cell separation in Saccharomyces cerevisiae. Bidlingmaier, S., Weiss, E.L., Seidel, C., Drubin, D.G., Snyder, M. Mol. Cell. Biol. (2001) [Pubmed]
  2. RAM: a conserved signaling network that regulates Ace2p transcriptional activity and polarized morphogenesis. Nelson, B., Kurischko, C., Horecka, J., Mody, M., Nair, P., Pratt, L., Zougman, A., McBroom, L.D., Hughes, T.R., Boone, C., Luca, F.C. Mol. Biol. Cell (2003) [Pubmed]
  3. The fission yeast MO25 protein functions in polar growth and cell separation. Mendoza, M., Redemann, S., Brunner, D. Eur. J. Cell Biol. (2005) [Pubmed]
  4. Roles of the RAM signaling network in cell cycle progression in Saccharomyces cerevisiae. Bogomolnaya, L.M., Pathak, R., Guo, J., Polymenis, M. Curr. Genet. (2006) [Pubmed]
  5. Hym1p affects cell cycle progression in Saccharomyces cerevisiae. Bogomolnaya, L.M., Pathak, R., Guo, J., Cham, R., Aramayo, R., Polymenis, M. Curr. Genet. (2004) [Pubmed]
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