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Gene Review

RPC10  -  DNA-directed RNA polymerase core subunit...

Saccharomyces cerevisiae S288c

Synonyms: ABC10-alpha, DNA-directed RNA polymerases I, II, and III subunit RPABC4, RNA polymerases I, II, and III subunit ABC4, RPB12, YHR143BW, ...
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High impact information on RPC10

  • The diverse functions of Saccharomyces cerevisiae RNA polymerase II are partitioned among its 12 subunits, designated RPB1-RPB12 [1].
  • Two additional common subunits, ABC10 alpha and ABC10 beta, are shared by yeast RNA polymerases [2].
  • Among these effects were the upregulation of two nuclear proteins encoding a Y'-helicase (a subtelomerically encoded protein whose function is to maintain telomeres) and a suppressor of rpc10 and rpb40 mutations (both rpc10 and rpb40 encode RNA polymerase subunits) [3].
  • Later, other groups isolated the genes for Rpb6 and Rpb12 and cDNA for Rpb10 [4].
  • RPC10 is a single copy gene localized on chromosome VIII [5].

Biological context of RPC10


Associations of RPC10 with chemical compounds


  1. RNA polymerase II subunit RPB9 is required for accurate start site selection. Hull, M.W., McKune, K., Woychik, N.A. Genes Dev. (1995) [Pubmed]
  2. Two additional common subunits, ABC10 alpha and ABC10 beta, are shared by yeast RNA polymerases. Carles, C., Treich, I., Bouet, F., Riva, M., Sentenac, A. J. Biol. Chem. (1991) [Pubmed]
  3. Transcriptional effects of the potent enediyne anti-cancer agent Calicheamicin gamma(I)(1). Watanabe, C.M., Supekova, L., Schultz, P.G. Chem. Biol. (2002) [Pubmed]
  4. Gene organization and protein sequence of the small subunits of Schizosaccharomyces pombe RNA polymerase II. Sakurai, H., Ishihama, A. Gene (1997) [Pubmed]
  5. RPC10 encodes a new mini subunit shared by yeast nuclear RNA polymerases. Treich, I., Carles, C., Riva, M., Sentenac, A. Gene Expr. (1992) [Pubmed]
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