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Gene Review

OYE2  -  Oye2p

Saccharomyces cerevisiae S288c

Synonyms: NADPH dehydrogenase 2, Old yellow enzyme 2, YHR179W
 
 
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Disease relevance of OYE2

 

High impact information on OYE2

  • We have previously shown that the NADPH oxidoreductase Oye2p protects the actin cytoskeleton from oxidative stress [2].
  • Loss of Oye2p leads to reactive oxygen species accumulation, activation of the oxidative stress response, nuclear fragmentation and DNA degradation, and premature chronological aging of yeast cells [2].
  • The oye2Delta phenotype can be completely suppressed by removing the potential for formation of the actin C285-C374 disulfide bond, the likely substrate of the Oye2p enzyme or by treating the cells with the clinically important reductant N-acetylcysteine [2].
  • Some of the physicochemical and kinetic properties of OYE2 and OYE3 have been determined [3].
  • The deduced amino acid sequence of this ORF predicts a protein of 398 residues with 84% similarity in its full length to OYE1 from Saccharomyces carlsbergensis and OYE2 from Saccharomyces cerevisiae [4].

References

  1. Production of a doubly chiral compound, (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexanone, by two-step enzymatic asymmetric reduction. Wada, M., Yoshizumi, A., Noda, Y., Kataoka, M., Shimizu, S., Takagi, H., Nakamori, S. Appl. Environ. Microbiol. (2003) [Pubmed]
  2. Conserved actin cysteine residues are oxidative stress sensors that can regulate cell death in yeast. Farah, M.E., Amberg, D.C. Mol. Biol. Cell (2007) [Pubmed]
  3. A new old yellow enzyme of Saccharomyces cerevisiae. Niino, Y.S., Chakraborty, S., Brown, B.J., Massey, V. J. Biol. Chem. (1995) [Pubmed]
  4. Nucleotide sequence and chromosomal localization of the gene encoding the Old Yellow Enzyme from Kluyveromyces lactis. Miranda, M., Ramírez, J., Guevara, S., Ongay-Larios, L., Peña, A., Coria, R. Yeast (1995) [Pubmed]
 
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