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ECM10  -  Hsp70 family ATPase ECM10

Saccharomyces cerevisiae S288c

Synonyms: Extracellular mutant protein 10, Heat shock protein SSC3, mitochondrial, SSC3, YEL030W
 
 
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High impact information on ECM10

  • Mitochondria of the yeast Saccharomyces cerevisiae contain three different Hsp70 chaperones, Ssc1, Ecm10 and Ssq1 [1].
  • Like Ssc1, Ecm10 interacts with the nucleotide exchange factor Mge1 in an ATP-dependent manner [2].
  • Overexpression of Ecm10 mitigates protein import defects in ssc1 mutants suggesting that Ecm10 can play a role in protein translocation [2].
  • Ecm10p was initially identified as a cell wall synthesis-related gene product [Genetics 147 (1997) 435] and also reported as a mitochondrial protein which was partially capable of compensating the phenotypic defect by SSC1 gene mutation [FEBS Lett. 487 (2000) 307] [3].

References

  1. The mitochondrial proteins Ssq1 and Jac1 are required for the assembly of iron sulfur clusters in mitochondria. Lutz, T., Westermann, B., Neupert, W., Herrmann, J.M. J. Mol. Biol. (2001) [Pubmed]
  2. Ecm10, a novel hsp70 homolog in the mitochondrial matrix of the yeast Saccharomyces cerevisiae. Baumann, F., Milisav, I., Neupert, W., Herrmann, J.M. FEBS Lett. (2000) [Pubmed]
  3. Ecm10p localizes in yeast mitochondrial nucleoids and its overexpression induces extensive mitochondrial DNA aggregations. Sakasegawa, Y., Hachiya, N.S., Tsukita, S., Kaneko, K. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
 
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