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Gene Review

ADAM18  -  ADAM metallopeptidase domain 18

Homo sapiens

Synonyms: ADAM 18, ADAM27, Disintegrin and metalloproteinase domain-containing protein 18, TMDC3, Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III, ...
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High impact information on ADAM18

  • In this study, we searched for ADAMs that may function in spermatogenesis or fertilization, and have cloned and sequenced four new mouse ADAM cDNAs: ADAM 24, ADAM 25, ADAM 26 and ADAM 27 [1].
  • Using RNA extracted from testes of pre-pubertal males of increasing age (8-40days), we found that adult levels of transcription, assessed in Northern blots, are reached by day 20 (ADAM 27), day 25 (ADAMs 24 and 25) and in the range day 25-50 (ADAM 26) [1].
  • In common with orthologues from other species, human tMDC III contains a putative integrin-binding glu-cys-asp (ECD) motif, the relevance of which is discussed in the context of a possible role in oolemma binding [2].
  • Human tMDC III: a sperm protein with a potential role in oocyte recognition [2].
  • Using a PCR-based approach, we have determined the complete nucleotide sequence of human tMDC III cDNA which, unlike the three non-functional genes, contains an uninterrupted open reading frame encoding a full-length MDC protein [2].


  1. Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization. Zhu, G.Z., Lin, Y., Myles, D.G., Primakoff, P. Gene (1999) [Pubmed]
  2. Human tMDC III: a sperm protein with a potential role in oocyte recognition. Frayne, J., Hurd, E.A., Hall, L. Mol. Hum. Reprod. (2002) [Pubmed]
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